Protein Info for Rv1278 in Mycobacterium tuberculosis H37Rv

Annotation: Hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 875 PF13175: AAA_15" amino acids 2 to 61 (60 residues), 32.9 bits, see alignment 8.3e-12 PF13514: AAA_27" amino acids 2 to 72 (71 residues), 29.2 bits, see alignment E=1e-10 PF13476: AAA_23" amino acids 5 to 70 (66 residues), 30.7 bits, see alignment 7.1e-11

Best Hits

Swiss-Prot: 100% identical to Y1278_MYCTO: Uncharacterized protein MT1315 (MT1315) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: None (inferred from 100% identity to mtf:TBFG_11304)

Predicted SEED Role

"DNA double-strand break repair Rad50 ATPase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (875 amino acids)

>Rv1278 Hypothetical protein (Mycobacterium tuberculosis H37Rv)
VKLHRLALTNYRGIAHRDVEFPDHGVVVVCGANEIGKSSMVEALDLLLEYKDRSTKKEVK
QVKPTNADVGSEVIAEISSGPYRFVYRKRFHKRCETELTVLAPRREQLTGDEAHERVRTM
LAETVDTELWHAQRVLQAASTAAVDLSGCDALSRALDLAAGDDAALSGTESLLIERIEAE
YARYFTPTGRPTGEWSAAVSRLAAAEAAVADCAAAVAEVDDGVRRHTELTEQVAELSQQL
LAHQLRLEAARVAAEKIAAITDDAREAKLIATAAAATSGASTAAHAGRLGLLTEIDTRTA
AVVAAEAKARQAADEQATARAEAEACDAALTEATQVLTAVRLRAESARRTLDQLADCEEA
DRLAARLARIDDIEGDRDRVCAELSAVTLTEELLSRIERAAAAVDRGGAQLASISAAVEF
TAAVDIELGVGDQRVSLSAGQSWSVTATGPTEVKVPGVLTARIVPGATALDFQAKYAAAQ
QELADALAAGEVADLAAARSADLCRRELLSRRDQLTATLAGLCGDEQVDQLRSRLEQLCA
GQPAELDLVSTDTATARAELDAVEAARIAAEKDCETRRQIAAGAARRLAETSTRATVLQN
AAAAESAELGAAMTRLACERASVGDDELAAKAEADLRVLQTAEQRVIDLADELAATAPDA
VAAELAEAADAVELLRERHDEAIRALHEVGVELSVFGTQGRKGKLDAAETEREHAASHHA
RVGRRARAARLLRSVMARHRDTTRLRYVEPYRAELHRLGRPVFGPSFEVEVDTDLRIRSR
TLDDRTVPYECLSGGAKEQLGILARLAGAALVAKEDAVPVLIDDALGFTDPERLAKMGEV
FDTIGADGQVIVLTCSPTRYGGVKGAHRIDLDAIQ