Protein Info for Rv1237 in Mycobacterium tuberculosis H37Rv

Annotation: Probable sugar-transport integral membrane protein ABC transporter SugB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 274 transmembrane" amino acids 7 to 29 (23 residues), see Phobius details amino acids 66 to 90 (25 residues), see Phobius details amino acids 101 to 122 (22 residues), see Phobius details amino acids 137 to 157 (21 residues), see Phobius details amino acids 178 to 203 (26 residues), see Phobius details amino acids 240 to 259 (20 residues), see Phobius details PF00528: BPD_transp_1" amino acids 80 to 266 (187 residues), 75.2 bits, see alignment E=2.8e-25

Best Hits

Swiss-Prot: 100% identical to SUGB_MYCTO: Trehalose transport system permease protein SugB (sugB) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K02026, multiple sugar transport system permease protein (inferred from 100% identity to mtf:TBFG_11262)

MetaCyc: 100% identical to ABC-type trehalose transporter integral membrane protein (Mycobacterium tuberculosis H37Rv)
7.5.2.-

Predicted SEED Role

"Maltose/maltodextrin ABC transporter, permease protein MalG" in subsystem Maltose and Maltodextrin Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (274 amino acids)

>Rv1237 Probable sugar-transport integral membrane protein ABC transporter SugB (Mycobacterium tuberculosis H37Rv)
VGARRATYWAVLDTLVVGYALLPVLWIFSLSLKPTSTVKDGKLIPSTVTFDNYRGIFRGD
LFSSALINSIGIGLITTVIAVVLGAMAAYAVARLEFPGKRLLIGAALLITMFPSISLVTP
LFNIERAIGLFDTWPGLILPYITFALPLAIYTLSAFFREIPWDLEKAAKMDGATPGQAFR
KVIVPLAAPGLVTAAILVFIFAWNDLLLALSLTATKAAITAPVAIANFTGSSQFEEPTGS
IAAGAIVITIPIIVFVLIFQRRIVAGLTSGAVKG