Protein Info for Rv1183 in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved transmembrane transport protein MmpL10

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1002 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 171 to 189 (19 residues), see Phobius details amino acids 196 to 222 (27 residues), see Phobius details amino acids 228 to 248 (21 residues), see Phobius details amino acids 270 to 292 (23 residues), see Phobius details amino acids 304 to 327 (24 residues), see Phobius details amino acids 357 to 378 (22 residues), see Phobius details amino acids 803 to 822 (20 residues), see Phobius details amino acids 829 to 854 (26 residues), see Phobius details amino acids 860 to 881 (22 residues), see Phobius details amino acids 902 to 924 (23 residues), see Phobius details amino acids 931 to 953 (23 residues), see Phobius details TIGR00833: transport protein" amino acids 1 to 967 (967 residues), 930 bits, see alignment E=8.8e-284 PF03176: MMPL" amino acids 30 to 357 (328 residues), 371.3 bits, see alignment E=1.9e-115 amino acids 635 to 967 (333 residues), 260.1 bits, see alignment E=1.3e-81

Best Hits

Swiss-Prot: 100% identical to MMPLA_MYCBO: Probable transport protein MmpL10 (mmpL10) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mbb:BCG_1245)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1002 amino acids)

>Rv1183 Probable conserved transmembrane transport protein MmpL10 (Mycobacterium tuberculosis H37Rv)
VVGCWVALALVLPMAVPSLAEMAQRHPVAVLPADAPSSVAVRQMAEAFHESGSENILVVL
LTDEKGLGAADENVYHTLVDRLRNDAKDVVMLQDFLTTPPLREVLGSKDGKAWILPIGLA
GDLGTPKSYHAYTDVERIVKRTVAGTTLTANVTGPAATVADLTDAGARDRASIELAIAVM
LLVILMVIYRNPVTMLLPLVTIGASLMTAQALVAGVSLVGGLAVSNQAIVLLSAMIAGAG
TDYAVFLISRYHEYVRLGEHPERAVQRAMMSVGKVIAASAATVGITFLGMRFAKLGVFST
VGPALAIGIAVSFLAAVTLLPAILVLASPRGWVAPRGERMATFWRRAGTRIVRRPKAYLG
ASLIGLVALASCASLAHFNYDDRKQLPPSDPSSVGYAAMEHHFSVNQTIPEYLIIHSAHD
LRTPRGLADLEQLAQRVSQIPGVAMVRGVTRPNGETLEQARATYQAGQVGNRLGGASRMI
DERTGDLNRLASGANLLADNLGDVRGQVSRAVAGVRSLVDALAYIQNQFGGNKTFNEIDN
AARLVSNIHALGDALQVNFDGIANSFDWLDSVVAALDTSPVCDSNPMCGNARVQFHKLQT
ARDNGTLDKVVGLARQLQSTRSPQTVSAVVNDLGRSLNSVVRSLKSLGLDNPDAARARLI
SMQNGANDLASAGRQVADGVQMLVDQTKNMGIGLNQASAFLMAMGNDASQPSMAGFNVPP
QVLKSEEFKKVAQAFISPDGHTVRYFIQTDLNPFSTAAMDQVNTIIDTAKGAQPNTSLAD
ASISMSGYPVMLRDIRDYYERDMRLIVAVTVVVVILILMALLRAIVAPLYLVGSVVISYM
SAIGLGVVVFQVFLGQELHWSVPGLAFVVLVAVGADYNMLLASRLRDESALGVRSSVIRT
VRCTGGVITAAGLIFAASMSGLLFSSIGTVVQGGFIIGVGILIDTFVVRTITVPAMATLL
GRASWWPGHPWQRCAPEEGQMSARMSARTKTVFQAVADGSKR