Protein Info for Rv1146 in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved transmembrane transport protein MmpL13b

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 470 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 65 to 86 (22 residues), see Phobius details amino acids 232 to 254 (23 residues), see Phobius details amino acids 261 to 279 (19 residues), see Phobius details amino acids 299 to 318 (20 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details PF03176: MMPL" amino acids 202 to 422 (221 residues), 81.9 bits, see alignment E=2.2e-27

Best Hits

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mtu:Rv1146)

Predicted SEED Role

"Transmembrane transport protein MmpL13"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (470 amino acids)

>Rv1146 Probable conserved transmembrane transport protein MmpL13b (Mycobacterium tuberculosis H37Rv)
VATVAFVATASIVITPAAIVLLGPRLDALDVRRLVRRLLGRPDPVHKPVKQLFWYRSSKF
VMRRWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDFGHDPATQ
IPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGSWVGTPRGATGLAEGSAF
LTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVVMAGVAQVNRDSVDAVTDRLPMVLGLIA
AITYVLLFLLTGSVVLPAKALVCNVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMP
VLLFCIAFGLSMDYEVFLVSRIREYWLESGAARPARRSVAEVHAANDESVALGVARTGRV
ITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVPAFMHVTGRWNWWA
PRPLAWLHERFGVSEAAEPVSRRRSHAGGLGKIAGRSDGQTIPASLTRNG