Protein Info for Rv1091 in Mycobacterium tuberculosis H37Rv

Annotation: PE-PGRS family protein PE_PGRS22

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 853 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00934: PE" amino acids 4 to 94 (91 residues), 117.5 bits, see alignment E=2.5e-38 PF21526: PGRS" amino acids 122 to 190 (69 residues), 56.5 bits, see alignment E=2.9e-19

Best Hits

KEGG orthology group: None (inferred from 97% identity to mbb:BCG_1151)

Predicted SEED Role

"PE_PGRS family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (853 amino acids)

>Rv1091 PE-PGRS family protein PE_PGRS22 (Mycobacterium tuberculosis H37Rv)
MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALLAAGADEVSAAIAALFGAHGQ
AYQTVSAQASAFHAQFVQALTGGGGAYAAAEAANVSAAQSTDQRLLDLINGPTQALLGRP
LIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTAGVAGGNGGAAGLIGNGGAGGGGGAGAA
GGNGGAGGWLYGNGGAGGAGGTSVIPGVAGGNGGAGGSAGLWGTGGAGGDGGNGRSGPVN
VAGSAGGNGGAGGAAGLFGDAGAGGNGGKGGAGGAAFSINFTAGDGGAGGAGGSGGHALL
WGAGGAGGNGGSGGTGGAGGSTAGAGGNGGAGGGGGTGGLLFGNGGAGGHGAAAGNGLAA
GNGVSSSGGGGAGGTGGAGGDGGAGGAGGNARLWGVGGAGGAGGDGGAGGAGGKGGSGLS
GNANGGAGGDSGRGGTGGAGGEGGAAGLLVGTGGHGGDGGAGGAAVKGGDGGAAAGTGIA
GAGGRGGAGGSGGSGGDGGGGAAGPAGWLFGDGGAGGNGGAAAAGGAGGQAGGGGGNGGN
GGNGGNGGNGGNGATGGWLYGNGGAGGQGATAGAGGAGANGVSSTNGGGTGGNGGIGGTG
GSGGAGGNAGLLGVGGAGGHGASGGAGDRGGAGGTGFISSDGGAGGDGGDGGNGGAGGTG
GLLFGAGGNGGPGGSGGAADIGGNGGAGNGGGTDGNGGNGGSGGGAGSGGDGGGAGGNGA
WLFGNGGAGGGGGKGGNGAGGGLGGGSFGLPGLNGSGGDGGDGGNGAPGGVLYGNGGAGG
QGSSGGIGGPGATGGAGGKGGDGGDAQLIGDGGNGGNGGAGGTGGTPGPGGPGGSGGLGG
LLFGQTGTAGVSP