Protein Info for Rv1085c in Mycobacterium tuberculosis H37Rv

Annotation: Possible hemolysin-like protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 242 transmembrane" amino acids 39 to 62 (24 residues), see Phobius details amino acids 68 to 88 (21 residues), see Phobius details amino acids 109 to 127 (19 residues), see Phobius details amino acids 133 to 152 (20 residues), see Phobius details amino acids 159 to 179 (21 residues), see Phobius details amino acids 185 to 206 (22 residues), see Phobius details amino acids 218 to 241 (24 residues), see Phobius details PF03006: HlyIII" amino acids 31 to 234 (204 residues), 176.5 bits, see alignment E=3.4e-56 TIGR01065: channel protein, hemolysin III family" amino acids 34 to 241 (208 residues), 217.9 bits, see alignment E=5.1e-69

Best Hits

Swiss-Prot: 100% identical to Y1114_MYCBO: UPF0073 membrane protein Mb1114c (BQ2027_MB1114C) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K11068, hemolysin III (inferred from 100% identity to mra:MRA_1095)

Predicted SEED Role

"COG1272: Predicted membrane protein hemolysin III homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (242 amino acids)

>Rv1085c Possible hemolysin-like protein (Mycobacterium tuberculosis H37Rv)
MSGQADTATTAEARTPAHAAHHLVEGVARVLTKPRFRGWIHVYSAGTAVLAGASLVAVSW
AVGSAKAGLTTLAYTAATITMFTVSATYHRVNWKSATARNWMKRADHSMIFVFIAGSYTP
FALLALPAHDGRVVLSIVWGGAIAGILLKMCWPAAPRSVGVPLYLLLGWVAVWYTATILH
NAGVTALVLLFVGGALYSIGGILYAVRWPDPWPTTFGYHEFFHACTAVAAICHYIAMWFV
VF