Protein Info for Rv1049 in Mycobacterium tuberculosis H37Rv

Annotation: Probable transcriptional repressor protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 148 PF12802: MarR_2" amino acids 33 to 95 (63 residues), 41.7 bits, see alignment E=1e-14 PF13545: HTH_Crp_2" amino acids 53 to 89 (37 residues), 28.2 bits, see alignment E=1.5e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to mbt:JTY_1079)

Predicted SEED Role

"Organic hydroperoxide resistance transcriptional regulator" in subsystem Oxidative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (148 amino acids)

>Rv1049 Probable transcriptional repressor protein (Mycobacterium tuberculosis H37Rv)
MGKGAAFDECACYTTRRAARQLGQAYDRALRPSGLTNTQFSTLAVISLSEGSAGIDLTMS
ELAARIGVERTTLTRNLEVMRRDGLVRVMAGADARCKRIELTAKGRAALQKAVPLWRGVQ
AEVTASVGDWPRVRRDIANLGQAAEACR