Protein Info for Rv1030 in Mycobacterium tuberculosis H37Rv

Annotation: Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 709 transmembrane" amino acids 53 to 71 (19 residues), see Phobius details amino acids 83 to 102 (20 residues), see Phobius details amino acids 237 to 260 (24 residues), see Phobius details amino acids 269 to 293 (25 residues), see Phobius details amino acids 611 to 629 (19 residues), see Phobius details amino acids 642 to 662 (21 residues), see Phobius details amino acids 682 to 707 (26 residues), see Phobius details TIGR01497: K+-transporting ATPase, B subunit" amino acids 25 to 703 (679 residues), 1026 bits, see alignment E=0 TIGR01494: HAD ATPase, P-type, family IC" amino acids 92 to 358 (267 residues), 112.6 bits, see alignment E=1.7e-36 amino acids 463 to 626 (164 residues), 128.7 bits, see alignment E=2.1e-41 PF00122: E1-E2_ATPase" amino acids 125 to 301 (177 residues), 116.3 bits, see alignment E=1.2e-37 PF00702: Hydrolase" amino acids 319 to 557 (239 residues), 80.8 bits, see alignment E=1.8e-26

Best Hits

Swiss-Prot: 100% identical to KDPB_MYCBO: Potassium-transporting ATPase ATP-binding subunit (kdpB) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K01547, K+-transporting ATPase ATPase B chain [EC: 3.6.3.12] (inferred from 100% identity to mra:MRA_1038)

MetaCyc: 68% identical to K+ transporting P-type ATPase subunit KdpB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-2 [EC: 7.2.2.6]

Predicted SEED Role

"Potassium-transporting ATPase B chain (EC 3.6.3.12) (TC 3.A.3.7.1)" in subsystem Potassium homeostasis (EC 3.6.3.12, TC 3.A.3.7.1)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.12

Use Curated BLAST to search for 3.6.3.12 or 7.2.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (709 amino acids)

>Rv1030 Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B) (Mycobacterium tuberculosis H37Rv)
VMIARMETSATAAAATSAPRLRLAKRSLFDPMIVRSALPQSLRKLAPRVQARNPVMLVVL
VGAVITTLAFLRDLASSTAQENVFNGLVAAFLWFTVLFANFAEAMAEGRGKAQAAALRKV
RSETMANRRTAAGNIESVPSSRLDLDDVVEVSAGETIPSDGEIIEGIASVDESAITGESA
PVIRESGGDRSAVTGGTVVLSDRIVVRITAKQGQTFIDRMIALVEGAARQQTPNEIALNI
LLAGLTIIFLLAVVTLQPFAIYSGGGQRVVVLVALLVCLIPTTIGALLSAIGIAGMDRLV
QHNVLATSGRAVEAAGDVNTLLLDKTGTITLGNRQATEFVPINGVSAEAVADAAQLSSLA
DETPEGRSIVVLAKDEFGLRARDEGVMSHARFVPFTAETRMSGVDLAEVSGIRRIRKGAA
AAVMKWVRDHGGHPTEEVGAIVDGISSGGGTPLVVAEWTDNSSARAIGVVHLKDIVKVGI
RERFDEMRRMSIRTVMITGDNPATAKAIAQEAGVDDFLAEATPEDKLALIKREQQGGRLV
AMTGDGTNDAPALAQADVGVAMNTGTQAAREAGNMVDLDSDPTKLIEVVEIGKQLLITRG
ALTTFSIANDVAKYFAIIPAMFVGLYPVLDKLNVMALHSPRSAILSAVIFNALVIVALIP
LALRGVRFRAESASAMLRRNLLIYGLGGLVVPFIGIKLVDLVIVALGVS