Protein Info for Rv0969 in Mycobacterium tuberculosis H37Rv

Annotation: Probable metal cation transporter P-type ATPase CtpV

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 770 transmembrane" amino acids 141 to 159 (19 residues), see Phobius details amino acids 165 to 184 (20 residues), see Phobius details amino acids 196 to 214 (19 residues), see Phobius details amino acids 221 to 238 (18 residues), see Phobius details amino acids 375 to 397 (23 residues), see Phobius details amino acids 403 to 425 (23 residues), see Phobius details amino acids 717 to 734 (18 residues), see Phobius details amino acids 740 to 758 (19 residues), see Phobius details TIGR01511: copper-translocating P-type ATPase" amino acids 179 to 761 (583 residues), 597.7 bits, see alignment E=4.9e-183 TIGR01525: heavy metal translocating P-type ATPase" amino acids 198 to 760 (563 residues), 650.8 bits, see alignment E=4.3e-199 TIGR01494: HAD ATPase, P-type, family IC" amino acids 231 to 737 (507 residues), 306.5 bits, see alignment E=5.2e-95 PF00122: E1-E2_ATPase" amino acids 259 to 436 (178 residues), 193.2 bits, see alignment E=4.5e-61 PF00702: Hydrolase" amino acids 454 to 672 (219 residues), 135.9 bits, see alignment E=3.5e-43

Best Hits

Swiss-Prot: 100% identical to CTPV_MYCTO: Probable copper-exporting P-type ATPase V (ctpV) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K12956, cation-transporting ATPase V [EC: 3.6.3.-] (inferred from 100% identity to mra:MRA_0976)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-, 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.- or 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (770 amino acids)

>Rv0969 Probable metal cation transporter P-type ATPase CtpV (Mycobacterium tuberculosis H37Rv)
MRVCVTGFNVDAVRAVAIEETVSQVTGVHAVHAYPRTASVVIWYSPELGDTAAVLSAITK
AQHVPAELVPARAPHSAGVRGVGVVRKITGGIRRMLSRPPGVDKPLKASRCGGRPRGPVR
GSASWPGEQNRRERRTWLPRVWLALPLGLLALGSSMFFGAYPWAGWLAFAATLPVQFVAG
WPILRGAVQQARALTSNMDTLIALGTLTAFVYSTYQLFAGGPLFFDTSALIIAFVVLGRH
LEARATGKASEAISKLLELGAKEATLLVDGQELLVPVDQVQVGDLVRVRPGEKIPVDGEV
TDGRAAVDESMLTGESVPVEKTAGDRVAGATVNLDGLLTVRATAVGADTALAQIVRLVEQ
AQGDKAPVQRLADRVSAVFVPAVIGVAVATFAGWTLIAANPVAGMTAAVAVLIIACPCAL
GLATPTAIMVGTGRGAELGILVKGGEVLEASKKIDTVVFDKTGTLTRARMRVTDVIAGQR
RQPDQVLRLAAAVESGSEHPIGAAIVAAAHERGLAIPAANAFTAVAGHGVRAQVNGGPVV
VGRRKLVDEQHLVLPDHLAAAAVEQEERGRTAVFVGQDGQVVGVLAVADTVKDDAADVVG
RLHAMGLQVAMITGDNARTAAAIAKQVGIEKVLAEVLPQDKVAEVRRLQDQGRVVAMVGD
GVNDAPALVQADLGIAIGTGTDVAIEASDITLMSGRLDGVVRAIELSRQTLRTIYQNLGW
AFGYNTAAIPLAALGALNPVVAGAAMGFSSVSVVTNSLRLRRFGRDGRTA