Protein Info for Rv0890c in Mycobacterium tuberculosis H37Rv

Annotation: Probable transcriptional regulatory protein (probably LuxR-family)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 882 PF08281: Sigma70_r4_2" amino acids 820 to 863 (44 residues), 28.5 bits, see alignment 9.5e-11 PF00196: GerE" amino acids 820 to 874 (55 residues), 66.6 bits, see alignment 1.2e-22

Best Hits

Swiss-Prot: 100% identical to Y890_MYCTU: Putative HTH-type transcriptional regulator Rv0890c (Rv0890c) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mbb:BCG_0942c)

Predicted SEED Role

"Adenylyl cyclase class-3/4/guanylyl cyclase / Disease resistance domain-containing protein / Tetratricopeptide repeat-containing protein / Transcriptional regulator, LuxR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (882 amino acids)

>Rv0890c Probable transcriptional regulatory protein (probably LuxR-family) (Mycobacterium tuberculosis H37Rv)
VRALLAQNRLVTLCGTGGVGKTRLAIQIASASELRDGLCFVDLAPITESGIVAATAARAV
GLPDQPGRSTMDSLRRFIGNRRMLMVLDNCEHLLDACAALVVELLGACPELTILATSREP
IGMAGEITWRVPSMSITDEAVELFADRASRVQPGFTIANHNAAAVGEICRRLDGIPLAIE
FAAARVRSMSPLEIADGLDDCFRLLAGGVRGAVQRQQTLRASIDWSHALLTETEQILFRR
LAPFVGGFDLAAVRAVAAGSDLDPFSVLDQLTLLVDKSLVVADDCQGRTRYRLLETVRRY
ALEKLGDSGEADVHARHRDYYTALAASLNTPADNDHQRLVARAETEIDNLRAAFAWSREN
GHITEALQLASSLQPIWFGRAHLREGLSWFNSILEDQRFHRLAVSTAVRARALADKAMLS
TWLATSPVGATDIIAPAQQALAMAREVGDPAALVRALTACGCSSGYNAEAAAPYFAEATD
LARAIDDKWTLCQILYWRGVGTCISGDPNALRAAAEECRDLADTIGDRFVSRHCSLWLSL
AQMWAGNLTEALELSREITAEAEASNDVPTKVLGLYTQAQVLAYCGASAAHAIAGACIAA
ATELGGVYQGIGYAAMTYAALAAGDVTAALEASDAARPILRAQPDQVTMHQVLMAQLALA
GGDAIAARQFANDAVDATNGWHRMVALTIRARVATARGEPELARDDAHAALACGAELHIY
QGMPDAMELLAGLAGEVGSHSEGVRLLGAAAALRQQTRQVRFKIWDAGYQASVTALREAM
GDEDFDRAWAEGAALSTDEAIAYAQRGRGERKRPARGWGSLTPTERDVVRLVSEGLSNKD
IAKRLFVSPRTVQTHLTHVYAKLGLPSRVQLVDEAARRGSPS