Protein Info for Rv0803 in Mycobacterium tuberculosis H37Rv

Annotation: Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 754 PF18072: FGAR-AT_linker" amino acids 16 to 58 (43 residues), 63.5 bits, see alignment 3.1e-21 TIGR01736: phosphoribosylformylglycinamidine synthase II" amino acids 23 to 751 (729 residues), 837.1 bits, see alignment E=6.1e-256 PF00586: AIRS" amino acids 84 to 198 (115 residues), 98.8 bits, see alignment E=3.8e-32 amino acids 456 to 574 (119 residues), 85.5 bits, see alignment E=5.3e-28 PF02769: AIRS_C" amino acids 212 to 368 (157 residues), 130.8 bits, see alignment E=7.6e-42 amino acids 588 to 725 (138 residues), 86.8 bits, see alignment E=2.8e-28

Best Hits

Swiss-Prot: 100% identical to PURL_MYCBP: Phosphoribosylformylglycinamidine synthase subunit PurL (purL) from Mycobacterium bovis (strain BCG / Pasteur 1173P2)

KEGG orthology group: K01952, phosphoribosylformylglycinamidine synthase [EC: 6.3.5.3] (inferred from 100% identity to mbo:Mb0826)

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.5.3

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (754 amino acids)

>Rv0803 Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) (Mycobacterium tuberculosis H37Rv)
VLDTVEHAATTPDQPQPYGELGLKDDEYRRIRQILGRRPTDTELAMYSVMWSEHCSYKSS
KVHLRYFGETTSDEMRAAMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATG
VGGIVRDIMAMGARPVAVMDQLRFGAADAPDTRRVLDGVVRGIGGYGNSLGLPNIGGETV
FDPCYAGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASDTFD
AEGSRKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDGG
MTIQLDSVPLRAKEMTPAEVLCSESQERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTD
GDRLQITWHGETVVDVPPRTVAHEGPVYQRPVARPDTQDALNADRSAKLSRPVTGDELRA
TLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADGGMLRIDESTGRGIAVSTDASGRY
TLLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCA
DLGIPVTGGNVSFYNQTGSAAILPTPVVGVLGVIDDVRRRIPTGLGAEPGETLMLLGDTR
DEFDGSVWAQVTADHLGGLPPVVDLAREKLLAAVLSSASRDGLVSAAHDLSEGGLAQAIV
ESALAGETGCRIVLPEGADPFVLLFSESAGRVLVAVPRTEESRFRGMCEARGLPAVRIGV
VDQGSDAVEVQGLFAVSLAELRATSEAVLPRYFG