Protein Info for Rv0792c in Mycobacterium tuberculosis H37Rv

Annotation: Probable transcriptional regulatory protein (probably GntR-family)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 269 PF00392: GntR" amino acids 24 to 85 (62 residues), 60.5 bits, see alignment E=9.7e-21 PF07702: UTRA" amino acids 108 to 246 (139 residues), 108.8 bits, see alignment E=2.1e-35

Best Hits

KEGG orthology group: K03710, GntR family transcriptional regulator (inferred from 100% identity to mtb:TBMG_00808)

Predicted SEED Role

"PF00070 family, FAD-dependent NAD(P)-disulphide oxidoreductase" in subsystem Mercuric reductase

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (269 amino acids)

>Rv0792c Probable transcriptional regulatory protein (probably GntR-family) (Mycobacterium tuberculosis H37Rv)
MTSVKLDLDAADLRISRGSVPASTQLAEALKAQIIQQRLPRGGRLPSERELIDRSGLSRV
TVRAAVGMLQRQGWLVRRQGLGTFVADPVEQELSCGVRTITEVLLSCGVTPQVDVLSHQT
GPAPQRISETLGLVEVLCIRRRIRTGDQPLALVTAYLPPGVGPAVEPLLSGSADTETTYA
MWERRLGVRIAQATHEIHAAGASPDVADALGLAVGSPVLVVDRTSYTNDGKPLEVVVFHH
RPERYQFSVTLPRTLPGSGAGIIEKRDFA