Protein Info for Rv0782 in Mycobacterium tuberculosis H37Rv

Annotation: Probable protease II PtrBb [second part] (oligopeptidase B)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 552 PF02897: Peptidase_S9_N" amino acids 35 to 261 (227 residues), 164.9 bits, see alignment E=2.7e-52 PF00326: Peptidase_S9" amino acids 318 to 533 (216 residues), 219.5 bits, see alignment E=3.7e-69

Best Hits

KEGG orthology group: K01354, oligopeptidase B [EC: 3.4.21.83] (inferred from 100% identity to mra:MRA_0791)

Predicted SEED Role

"Protease II (EC 3.4.21.83)" (EC 3.4.21.83)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.83

Use Curated BLAST to search for 3.4.21.83

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (552 amino acids)

>Rv0782 Probable protease II PtrBb [second part] (oligopeptidase B) (Mycobacterium tuberculosis H37Rv)
VTNDIPCGSRIYAPENSTRTRSPGSERESPGQLTTTVYYTTVDAAWRPDTVWRYRLGSGE
SSERVYHEADDRFWLAVGRTRSNAYLLIAAGSSITSEVRYAHAADPTAQFSVVLPRRDGV
EYSVEHAVIAGQDRFLILHNDGAVNFTLVEAPVEDPARQRTLIAHRDDVRLDAVDALAGH
LVVSYRREALPRVQLWPIGPDGNYGEPEEISFDSELMSAGLGPNPNWDSPKLRVGAGSFV
TPVRIYDIDLVTGERTLLKEQPVLGGYRREDYVERRDWAYGDDGTRIPVSIVHRADIEFP
APALIYGYGAYEICEDPRFSIARLSLLDRGMVFVVAHVRGGGEMGRLWYENGKLLDKKNT
FTDFIAVARHLVDTGLTSQQQLVALGGSAGGLLMGAVANMAPDLFAGILAQVPFVDPLTT
ILDPSLPLTVTEWDEWGNPLNDSDVYAYVKSYSPYENVTAQKYPAILAMTSLNDTRVYYV
EPAKWVAALRHAKTDGNSVLLKTQMHAGHGGISGRYERWKETAFQYGWLLATADSDRYGG
GQGNDLDGAAPA