Protein Info for Rv0729 in Mycobacterium tuberculosis H37Rv

Annotation: Possible D-xylulose kinase XylB (xylulokinase) (xylulose kinase)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00370: FGGY_N
  • amino acids 7 to 104 (98 residues), 34.9 bits, E=1.3e-12
• PF02782: FGGY_C
  • amino acids 291 to 402 (112 residues), 84.1 bits, E=1.2e-27

Best Hits

KEGG orthology group: K00854, xylulokinase [EC: 2.7.1.17] (inferred from 99% identity to mbt:JTY_0749)

Predicted SEED Role

"Putative xylulose kinase (EC 2.7.1.17)" in subsystem Xylose utilization (EC 2.7.1.17)

MetaCyc Pathways

• superpathway of glucose and xylose degradation (14/17 steps found)
• D-arabinitol degradation I (1/2 steps found)
• D-xylose degradation I (1/2 steps found)
• xylitol degradation I (1/2 steps found)
• superpathway of pentose and pentitol degradation (6/42 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.17

Protein Sequence (448 amino acids)

>Rv0729 Possible D-xylulose kinase XylB (xylulokinase) (xylulose kinase) (Mycobacterium tuberculosis H37Rv)
VSRDDVTIGIDIGTTAVKAVAADDNGRVTARVRIGHQLAVPAPDRLEHDADEAWRRGPLA
ALDRLVGPDTRALAVAAMVPSLTAVDPAGRPITPGLLYGDARGRVPNASVARAQSVPSVG
ETAEFLRWTAGQALDASGYWPAPAVANYALSGEAVIDYATAVTTLPLFDGTGWNATACAD
CGVTVDRMPRVETFGVGVGQVRGTGAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIV
WTTISAARQVPGLWTIPHTAPGKSQIGGASNAGGLFLNWVDRVIGPGDPALADPRRVPVW
LPYIRGERTPFHEPDRRAVLDGVDLSQDAASVRRAAYEASGFVVRQLIELSGAPVARIVA
AGGGTRIQPWMQAIADATGRPVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWASTDR
IVEPSADWAGPTKERYRRFLALSGSKLA