Protein Info for Rv0723 in Mycobacterium tuberculosis H37Rv

Annotation: 50S ribosomal protein L15 RplO

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 146 TIGR01071: ribosomal protein uL15" amino acids 4 to 143 (140 residues), 160.2 bits, see alignment E=1.5e-51 PF00828: Ribosomal_L27A" amino acids 28 to 143 (116 residues), 113.7 bits, see alignment E=4.8e-37

Best Hits

Swiss-Prot: 99% identical to RL15_MYCTO: 50S ribosomal protein L15 (rplO) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K02876, large subunit ribosomal protein L15 (inferred from 99% identity to mbo:Mb0744)

Predicted SEED Role

"LSU ribosomal protein L15p (L27Ae)" in subsystem Ribosome LSU bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (146 amino acids)

>Rv0723 50S ribosomal protein L15 RplO (Mycobacterium tuberculosis H37Rv)
VTLKLHDLRPARGSKIARTRVGRGDGSKGKTAGRGTKGTRARKQVPVTFEGGQMPIHMRL
PKLKGFRNRFRTEYEIVNVGDINRLFPQGGAVGVDDLVAKGAVRKNALVKVLGDGKLTAK
VDVSAHKFSGSARAKITAAGGSATEL