Protein Info for Rv0658c in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved integral membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 238 transmembrane" amino acids 15 to 38 (24 residues), see Phobius details amino acids 45 to 67 (23 residues), see Phobius details amino acids 88 to 112 (25 residues), see Phobius details amino acids 132 to 154 (23 residues), see Phobius details amino acids 166 to 184 (19 residues), see Phobius details amino acids 190 to 211 (22 residues), see Phobius details amino acids 218 to 237 (20 residues), see Phobius details PF02517: Rce1-like" amino acids 133 to 222 (90 residues), 59.8 bits, see alignment E=1.3e-20

Best Hits

KEGG orthology group: K07052, (no description) (inferred from 99% identity to mtb:TBMG_00669)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (238 amino acids)

>Rv0658c Probable conserved integral membrane protein (Mycobacterium tuberculosis H37Rv)
VEAGRADTVAPSHRWGLGAFLVVELVFLVASTSLAVVLTGHGPVSAGVLALALAAPTVVA
AGLAILITRLRGNGLRTDLRLRWSWRGLRLGLMFGFGGMLVTIPASLVYTAIVGPEANSA
VVRIFGGVRASWPWALVVFLVVVFVAPLCEEIIYRGLLWGAVDRRWGRWAALVVTTVVFA
LAHLEFARAPLLVVVAIPIALARFYSGGLLASIVTHQVTNLLPGIVLLLGLTGAISLP