Protein Info for Rv0629c in Mycobacterium tuberculosis H37Rv

Annotation: Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 575 TIGR01447: exodeoxyribonuclease V, alpha subunit" amino acids 17 to 569 (553 residues), 608.4 bits, see alignment E=7.5e-187 PF21185: RecD_N" amino acids 21 to 100 (80 residues), 31.3 bits, see alignment E=9.6e-11 PF13604: AAA_30" amino acids 151 to 359 (209 residues), 111.4 bits, see alignment E=2.2e-35 PF13086: AAA_11" amino acids 151 to 234 (84 residues), 31.7 bits, see alignment E=6.5e-11 PF00580: UvrD-helicase" amino acids 152 to 243 (92 residues), 27.7 bits, see alignment E=1e-09 PF13245: AAA_19" amino acids 153 to 304 (152 residues), 120.8 bits, see alignment E=2.1e-38 PF13401: AAA_22" amino acids 162 to 298 (137 residues), 34.7 bits, see alignment E=9.3e-12 PF05127: Helicase_RecD" amino acids 167 to 285 (119 residues), 31.1 bits, see alignment E=9.9e-11 PF01443: Viral_helicase1" amino acids 497 to 544 (48 residues), 24.2 bits, see alignment 1.2e-08 PF13538: UvrD_C_2" amino acids 499 to 545 (47 residues), 53.7 bits, see alignment 7e-18

Best Hits

Swiss-Prot: 100% identical to RECD_MYCTO: RecBCD enzyme subunit RecD (recD) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K03581, exodeoxyribonuclease V alpha subunit [EC: 3.1.11.5] (inferred from 100% identity to mtf:TBFG_10640)

Predicted SEED Role

No annotation

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.5

Use Curated BLAST to search for 3.1.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (575 amino acids)

>Rv0629c Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) (Mycobacterium tuberculosis H37Rv)
VKLTDVDFAVEASGMVRAFNQAGVLDVSDVHVAQRLCALAGESDERVALAVAVAVRALRA
GSVCVDLLSIARVAGHDDLPWPDPADWLAAVRASPLLADPPVLHLYDDRLLYLDRYWREE
EQVCADLLALLTSRRPAGVPDLRRLFPTGFDEQRRAAEIALSQGVTVLTGGPGTGKTTTV
ARLLALVAEQAELAGEPRPRIALAAPTGKAAARLAEAVRREMAKLDATDRARLGDLHAVT
LHRLLGAKPGARFRQDRQNRLPHNVIVVDETSMVSLTLMARLAEAVRPGARLILVGDADQ
LASVEAGAVLADLVDGFSVRDDALVAQLRTSHRFGKVIGTLAEAIRAGDGDAVLGLLRSG
EERIEFVDDEDPAPRLRAVLVPHALRLREAALLGASDVALATLDEHRLLCAHRDGPTGVL
HWNRRVQAWLAEETGQPPWTPWYAGRPLLVTANDYGLRVYNGDTGVVLAGPTGLRAVISG
ASGPLDVATGRLGDVETMHAMTIHKSQGSQVDEVTVLMPQEDSRLLTRELLYTAVTRAKR
KVRVVGSEASVRAAIARRAVRASGLRMRLQSTGCG