Protein Info for Rv0618 in Mycobacterium tuberculosis H37Rv

Annotation: Probable galactose-1-phosphate uridylyltransferase GalTa [first part]

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01087: GalP_UDP_transf
  • amino acids 76 to 220 (145 residues), 95.9 bits, E=2.2e-31

Best Hits

KEGG orthology group: K00965, UDPglucose--hexose-1-phosphate uridylyltransferase [EC: 2.7.7.12] (inferred from 100% identity to mtu:Rv0618)

Predicted SEED Role

"Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)" in subsystem Lactose and Galactose Uptake and Utilization (EC 2.7.7.10)

MetaCyc Pathways

• D-galactose detoxification (3/3 steps found)
• D-galactose degradation I (Leloir pathway) (4/5 steps found)
• stachyose degradation (5/7 steps found)

KEGG Metabolic Maps

• Galactose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.10, 2.7.7.12

Use Curated BLAST to search for 2.7.7.10 or 2.7.7.12

Protein Sequence (231 amino acids)

>Rv0618 Probable galactose-1-phosphate uridylyltransferase GalTa [first part] (Mycobacterium tuberculosis H37Rv)
MSATPPPGGLDASVFIANERGRQLDEALPVGFCVVTAPTRWTLADGRDLLFFSLPGHVPA
PVSDRRPLPERDPAPSRLRFDRATGQWVIVAAQRQDRTYKPPAARCPLCPGPTGLSSEVP
APDYDVVVFENRFPSLAGAGIAPIGAPDGDGFVSAPGHGRCEVICFSADHTGSFAGLDPA
HARLVVHAWRHRTAELTALPGVAQVFCFENRGEEIGVTLPTRTARFTPIRI