Protein Info for Rv0576 in Mycobacterium tuberculosis H37Rv

Annotation: Probable transcriptional regulatory protein (possibly ArsR-family)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 434 PF12840: HTH_20" amino acids 6 to 52 (47 residues), 47.8 bits, see alignment 2.2e-16 PF01022: HTH_5" amino acids 8 to 52 (45 residues), 47.9 bits, see alignment 1.9e-16 PF10604: Polyketide_cyc2" amino acids 105 to 203 (99 residues), 35.5 bits, see alignment E=2.3e-12 PF08327: AHSA1" amino acids 115 to 228 (114 residues), 97.9 bits, see alignment E=1e-31 TIGR03083: uncharacterized Actinobacterial protein TIGR03083" amino acids 254 to 424 (171 residues), 83.9 bits, see alignment E=1.9e-27 TIGR03086: TIGR03086 family protein" amino acids 255 to 424 (170 residues), 119.8 bits, see alignment E=1.2e-38

Best Hits

KEGG orthology group: None (inferred from 100% identity to mbo:Mb0591)

Predicted SEED Role

"Transcriptional regulator, ArsR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (434 amino acids)

>Rv0576 Probable transcriptional regulatory protein (possibly ArsR-family) (Mycobacterium tuberculosis H37Rv)
MLEVAAEPTRRRLLQLLAPGERTVTQLASQFTVTRSAISQHLGMLAEAGLVTARKQGRER
YYRLDERGVLRLRALMESFWSDELDRLVADAAHYPPSQGDCAMPFEKAVVVPLDPTSTFA
LITQPDRLRRWMAVAARIELRTGGAYRWTVTPGHSAAGTVIDVDPGKRVVFTWGWEDHGD
PPPGGSTVTITLTPVDGGTEVRLVHDGLTAQQAARHAKGWNHFLDRLVVAGQRGDAGPDE
WAAAPDPLDELSCAEATLAVLQHVLRGIGASDLTRQTPCTEYDVSQLADHLLRSLAIIGA
AAGAQLAPRDVDAPLETQVADAAQAVMEAWRRRGLAGTVELNSNQVPATVPVGILCLEFL
VHAWDFAIATGSQVIASEPVSEYVLAVAGKVITPATRNSAGFAAPAAVGSFAPVLDRLIA
FTGRQPTAGHVSAT