Protein Info for Rv0499 in Mycobacterium tuberculosis H37Rv

Annotation: Conserved hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details PF13622: 4HBT_3" amino acids 32 to 119 (88 residues), 68.3 bits, see alignment E=5.6e-23 PF20789: 4HBT_3C" amino acids 171 to 288 (118 residues), 80 bits, see alignment E=2.1e-26

Best Hits

Swiss-Prot: 100% identical to Y510_MYCBO: Uncharacterized protein Mb0510 (BQ2027_MB0510) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: None (inferred from 100% identity to mtu:Rv0499)

Predicted SEED Role

"TesB-like acyl-CoA thioesterase 3"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (291 amino acids)

>Rv0499 Conserved hypothetical protein (Mycobacterium tuberculosis H37Rv)
MNALFTTAMALRPLDSDPGNPACRVFEGELNEHWTIGPKVHGGAMVALCANAARTAYGAA
GQQPMRQPVAVSASFLWAPDPGTMRLVTSIRKRGRRISVADVELTQGGRTAVHAVVTLGE
PEHFLPGVDGSGGASGTAPLLSANPVVELMAPEPPEGVVPIGPGHQLAGLVHLGEGCDVR
PVLSTLRSATDGRPPVIQLWARPRGVAPDALFALLCGDLSAPVTFAVDRTGWAPTVALTA
YLRALPADGWLRVLCTCVEIGQDWFDEDHIVVDRLGRIVVQTRQLAMVPAQ