Protein Info for Rv0450c in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved transmembrane transport protein MmpL4

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 967 transmembrane" amino acids 23 to 47 (25 residues), see Phobius details amino acids 203 to 232 (30 residues), see Phobius details amino acids 251 to 277 (27 residues), see Phobius details amino acids 303 to 325 (23 residues), see Phobius details amino acids 331 to 357 (27 residues), see Phobius details amino acids 380 to 403 (24 residues), see Phobius details amino acids 769 to 789 (21 residues), see Phobius details amino acids 795 to 818 (24 residues), see Phobius details amino acids 825 to 848 (24 residues), see Phobius details amino acids 875 to 893 (19 residues), see Phobius details amino acids 910 to 933 (24 residues), see Phobius details TIGR00833: transport protein" amino acids 27 to 935 (909 residues), 1238.6 bits, see alignment E=0 PF03176: MMPL" amino acids 59 to 388 (330 residues), 432.5 bits, see alignment E=5e-134 amino acids 610 to 943 (334 residues), 351.2 bits, see alignment E=2.7e-109

Best Hits

Swiss-Prot: 100% identical to MMPL4_MYCTO: Siderophore exporter MmpL4 (mmpL4) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mbb:BCG_0489c)

Predicted SEED Role

"Transmembrane transport protein MmpL4"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (967 amino acids)

>Rv0450c Probable conserved transmembrane transport protein MmpL4 (Mycobacterium tuberculosis H37Rv)
VSTKFANDSNTNARPEKPFIARMIHAFAVPIILGWLAVCVVVTVFVPSLEAVGQERSVSL
SPKDAPSFEAMGRIGMVFKEGDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQ
SVQDLWGDPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTPAPPGIKA
YVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVLLLITVGVELTAAR
GVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFIIGRYQEARQAGEDKEAAYYTMYR
GTAHVILGSGLTIAGATFCLSFARMPYFQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRF
GLFDPKRLLKVRGWRRVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFI
PANQGYAAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRVQAIT
RPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMATTIAVLTRMHSLMAE
MASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPIRSYFYWEKHCYGIPICWSFRSIFD
ALDGIDKLSEQIGVLLGDLREMDRLMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQ
MLEMSDNATAMGKAFDAAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGD
PQSPEGIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAISSLC
LIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHLHWLVLAMSVIVLLA
VGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVVTNAGLVFAVTMASMAVSDLRVIGQ
VGTTIGLGLLFDTLIVRSFMTPSIAALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLA
MSSDRLG