Protein Info for Rv0410c in Mycobacterium tuberculosis H37Rv

Annotation: Serine/threonine-protein kinase PknG (protein kinase G) (STPK G)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 transmembrane" amino acids 254 to 267 (14 residues), see Phobius details PF16919: PknG_rubred" amino acids 69 to 141 (73 residues), 140.3 bits, see alignment E=3.9e-45 PF00069: Pkinase" amino acids 151 to 345 (195 residues), 108.8 bits, see alignment E=8e-35 PF07714: PK_Tyr_Ser-Thr" amino acids 157 to 305 (149 residues), 47.8 bits, see alignment E=3.2e-16 PF16918: PknG_TPR" amino acids 409 to 748 (340 residues), 528.7 bits, see alignment E=1.3e-162

Best Hits

Swiss-Prot: 100% identical to PKNG_MYCTO: Serine/threonine-protein kinase PknG (pknG) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K14949, serine/threonine-protein kinase PknG [EC: 2.7.11.1] (inferred from 100% identity to mbb:BCG_0449c)

Predicted SEED Role

"serine/threonine protein kinase"

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.11.1

Use Curated BLAST to search for 2.7.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (750 amino acids)

>Rv0410c Serine/threonine-protein kinase PknG (protein kinase G) (STPK G) (Mycobacterium tuberculosis H37Rv)
MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDR
MATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSET
KGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVL
KGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL
KRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRI
NSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVL
KTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRS
TFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTL
DSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVW
YRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTND
GVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQ
IRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEAS
LRSLARVAPTQRHRYTLVDMANKVRPTSTF