Protein Info for Rv0407 in Mycobacterium tuberculosis H37Rv

Annotation: F420-dependent glucose-6-phosphate dehydrogenase Fgd1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 336 TIGR03554: glucose-6-phosphate dehydrogenase (coenzyme-F420)" amino acids 3 to 333 (331 residues), 734.3 bits, see alignment E=1.4e-225 TIGR03557: F420-dependent oxidoreductase, G6PDH family" amino acids 6 to 333 (328 residues), 251.2 bits, see alignment E=1.3e-78 PF00296: Bac_luciferase" amino acids 11 to 306 (296 residues), 224 bits, see alignment E=1.6e-70

Best Hits

Swiss-Prot: 100% identical to FGD_MYCTU: F420-dependent glucose-6-phosphate dehydrogenase (fgd1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mtc:MT0420)

MetaCyc: 100% identical to glucose-6-phosphate dehydrogenase (coenzyme-F420) monomer (Mycobacterium tuberculosis H37Rv)
RXN-11283 [EC: 1.1.98.2]

Predicted SEED Role

"F420-dependent glucose-6-phosphate dehydrogenase"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.98.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (336 amino acids)

>Rv0407 F420-dependent glucose-6-phosphate dehydrogenase Fgd1 (Mycobacterium tuberculosis H37Rv)
VAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHQGGHAPFSLSWMTA
VGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVFLGVGTGEALNEIATGYEG
AWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGASIYDVPDGGVPVYIAAGGPA
VAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAADRSVDGIDKMIEIKISYDPDPE
LALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQIAKRWIVASDPDEAVEKVGQY
VTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRRLG