Protein Info for Rv0373c in Mycobacterium tuberculosis H37Rv

Annotation: Probable carbon monoxyde dehydrogenase (large chain)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 799 TIGR02416: carbon-monoxide dehydrogenase, large subunit" amino acids 31 to 790 (760 residues), 1453.4 bits, see alignment E=0 PF01315: Ald_Xan_dh_C" amino acids 38 to 145 (108 residues), 125.4 bits, see alignment E=1.9e-40 PF02738: MoCoBD_1" amino acids 169 to 415 (247 residues), 247.5 bits, see alignment E=1.7e-77 PF20256: MoCoBD_2" amino acids 442 to 729 (288 residues), 298 bits, see alignment E=1.3e-92

Best Hits

Swiss-Prot: 59% identical to DCML_HYDPS: Carbon monoxide dehydrogenase large chain (cutL) from Hydrogenophaga pseudoflava

KEGG orthology group: K03520, carbon-monoxide dehydrogenase large subunit [EC: 1.2.99.2] (inferred from 100% identity to mtc:MT0388)

MetaCyc: 56% identical to carbon monoxide dehydrogenase large chain (Afipia carboxidovorans)

Predicted SEED Role

No annotation

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (799 amino acids)

>Rv0373c Probable carbon monoxyde dehydrogenase (large chain) (Mycobacterium tuberculosis H37Rv)
MTTIESRPPSPEDLADNAQQPCGHGRMMRKEDPRFIRGRGTYVDDVALPGMLHLAILRSP
YAHARIVRIDVTAAQAHPKVKAVVTGADLAAKGLAWMPTLANDVQAVLATDKTRFQGQEV
AFVVAEDRYSARDACELVDVDYEPRDPVVDARTALDPSAPVIRTDLEGKSDNHIFDWETG
DAAATEAVFAKADVVVQQEIVYPRVHPAPMETCGAVADLDPVTGKLTLWTTSQAPHAHRT
LYALVAGLPEHKIRVISPDIGGGFGNKVPIYPGYVCAIVASLLLDKPVKWMEDRSENLTS
TGFARDYIMVGEIAANRDGKILAIRSNVLADHGAFNAQAAPAKYPAGFFGVFTGSYDIEA
AYCHMTAVYTNKAPGGVAYACSFRITEAVYFVERLVDCLAFELKMDPAELRLRNLLRPNQ
FPYQSKTGWVYDSGDYETTMRKAMNMIGYEALRAEQKQRRARGELMGIGMSFFTEAVGAG
PRKDMDILGLGMADGCELRVHPTGKAVLRLSVQTQGQGHETTFAQIVAEELGIAPDDIEV
VHGDTDQTPFGLGTYGSRSTPVSGGAAALVARKVRDKAKIIASGMLEVSVADLQWEKGKF
HVKGDPSAAVTIADIAMRAHGAGDLPEGIEGGLDAEVCYNPSNLTYPYGAYFCVVDIDPG
TAVVKVRRFLAVDDCGTRINPMIIEGQVHGGIVDGIGMALMEMIAFDEDGNCLGGSLMDY
LIPTALEVPHLETGHTVTPSPHHPIGAKGIGESATVGSPPAVVNAVVDALAPFGVRHADM
PLTPSRVWEAMQGRATPPI