Protein Info for Rv0353 in Mycobacterium tuberculosis H37Rv

Annotation: Probable heat shock protein transcriptional repressor HspR (MerR family)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 126 PF00376: MerR" amino acids 15 to 50 (36 residues), 45.5 bits, see alignment E=7.7e-16 PF13411: MerR_1" amino acids 15 to 80 (66 residues), 64.3 bits, see alignment E=1.3e-21

Best Hits

KEGG orthology group: K13640, MerR family transcriptional regulator, heat shock protein HspR (inferred from 100% identity to mtu:Rv0353)

Predicted SEED Role

"HspR, transcriptional repressor of DnaK operon" in subsystem Heat shock dnaK gene cluster extended or Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (126 amino acids)

>Rv0353 Probable heat shock protein transcriptional repressor HspR (MerR family) (Mycobacterium tuberculosis H37Rv)
MAKNPKDGESRTFLISVAAELAGMHAQTLRTYDRLGLVSPRRTSGGGRRYSLHDVELLRQ
VQHLSQDEGVNLAGIKRIIELTSQVEALQSRLQEMAEELAVLRANQRREVAVVPKSTALV
VWKPRR