Protein Info for Rv0337c in Mycobacterium tuberculosis H37Rv
Annotation: Probable aspartate aminotransferase AspC (transaminase A) (ASPAT)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to AAT_MYCTO: Probable aspartate aminotransferase (aspC) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
KEGG orthology group: K14260, alanine-synthesizing transaminase [EC: 2.6.1.2 2.6.1.66] (inferred from 100% identity to mtf:TBFG_10342)MetaCyc: 59% identical to glutamate--pyruvate aminotransferase AlaA (Escherichia coli K-12 substr. MG1655)
Alanine transaminase. [EC: 2.6.1.2]
Predicted SEED Role
No annotation
MetaCyc Pathways
- anaerobic energy metabolism (invertebrates, cytosol) (7/7 steps found)
- superpathway of L-alanine biosynthesis (4/4 steps found)
- C4 photosynthetic carbon assimilation cycle, NAD-ME type (9/11 steps found)
- superpathway of anaerobic energy metabolism (invertebrates) (13/17 steps found)
- L-alanine biosynthesis I (2/2 steps found)
- L-alanine biosynthesis II (1/1 steps found)
- L-alanine degradation III (1/1 steps found)
- L-alanine degradation II (to D-lactate) (2/3 steps found)
- L-alanine degradation V (oxidative Stickland reaction) (1/2 steps found)
- pyruvate fermentation to acetate and alanine (1/3 steps found)
- C4 photosynthetic carbon assimilation cycle, PEPCK type (7/14 steps found)
- L-alanine degradation VI (reductive Stickland reaction) (1/6 steps found)
- superpathway of L-alanine fermentation (Stickland reaction) (3/9 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (23/56 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Carbon fixation in photosynthetic organisms
- Glutamate metabolism
- Valine, leucine and isoleucine biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.6.1.2 or 2.6.1.66
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (429 amino acids)
>Rv0337c Probable aspartate aminotransferase AspC (transaminase A) (ASPAT) (Mycobacterium tuberculosis H37Rv) VDNDGTIVDVTTHQLPWHTASHQRQRAFAQSAKLQDVLYEIRGPVHQHAARLEAEGHRIL KLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSQGILSARRAVVTRYELVPGFPRFDV DDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTASTSLAGGTPVHYLCDETQGWQ PDIADLESKITERTKALVVINPNNPTGAVYSCEILTQMVDLARKHQLLLLADEIYDKILY DDAKHISLASIAPDMLCLTFNGLSKAYRVAGYRAGWLAITGPKEHASSFIEGIGLLANMR LCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQRDIAWTKLNEIPGVSCVKPAGALYAF PRLDPEVYDIDDDEQLVLDLLLSEKILVTQGTGFNWPAPDHLRLVTLPWSRDLAAAIERL GNFLVSYRQ