Protein Info for Rv0286 in Mycobacterium tuberculosis H37Rv

Annotation: PPE family protein PPE4

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 513 transmembrane" amino acids 117 to 134 (18 residues), see Phobius details amino acids 147 to 168 (22 residues), see Phobius details amino acids 204 to 223 (20 residues), see Phobius details amino acids 235 to 260 (26 residues), see Phobius details amino acids 277 to 301 (25 residues), see Phobius details amino acids 309 to 330 (22 residues), see Phobius details PF00823: PPE" amino acids 6 to 168 (163 residues), 211.5 bits, see alignment E=8.2e-67 PF18878: PPE-PPW" amino acids 440 to 487 (48 residues), 74.2 bits, see alignment 6.5e-25

Best Hits

Swiss-Prot: 100% identical to PPE04_MYCTO: PPE family protein PPE4 (PPE4) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: None (inferred from 100% identity to mbt:JTY_0296)

Predicted SEED Role

"PPE family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (513 amino acids)

>Rv0286 PPE family protein PPE4 (Mycobacterium tuberculosis H37Rv)
MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYASTAAELSGLLGAVPGWAW
QGPSAEWYVAAHLPYVAWLTQASADAAGAAAQHEAAAAAYTTALAAMPTLAELAANHVIH
TVLVATNFFGINTIPITLNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNP
GGGAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQDPIGNSIKIIIAFLTN
PIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSPFLLPAGLGLGLAAIAFLPIVLAPA
VIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATASF
AYAVGGSGDWGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRSELRDYGDE
FLDMDSDSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVRAVGLTALAGDEFGNGPRM
PMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK