Protein Info for Rv0234c in Mycobacterium tuberculosis H37Rv

Annotation: Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 57 to 508 (452 residues), 478.4 bits, E=1e-147

Best Hits

Swiss-Prot: 100% identical to GABD1_MYCBO: Succinate-semialdehyde dehydrogenase [NADP(+)] 1 (gabD1) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 100% identity to mbo:Mb0239c)

MetaCyc: 100% identical to NADP-dependent succinate-semialdehyde dehydrogenase (Mycobacterium tuberculosis H37Rv)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)

MetaCyc Pathways

• TCA cycle IV (2-oxoglutarate decarboxylase) (8/9 steps found)
• superpathway of 4-aminobutanoate degradation (3/3 steps found)
• 4-aminobutanoate degradation I (2/2 steps found)
• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• GABA shunt I (3/4 steps found)
• GABA shunt II (3/4 steps found)
• 4-aminobutanoate degradation IV (1/3 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)
• 4-hydroxyphenylacetate degradation (3/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• superpathway of L-arginine and L-ornithine degradation (6/13 steps found)
• nicotine degradation II (pyrrolidine pathway) (2/11 steps found)
• nicotine degradation I (pyridine pathway) (5/17 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.24 or 1.2.1.79

Protein Sequence (511 amino acids)

>Rv0234c Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 (Mycobacterium tuberculosis H37Rv)
MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPAKDVSVPIATI
NPATGETVKTFTAATDDEVDAAIARAHRRFADYRQTSFAQRARWANATADLLEAEADQAA
AMMTLEMGKTLAAAKAEALKCAKGFRYYAENAEALLADEPADAAKVGASAAYGRYQPLGV
ILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTL
LVSSGAVEAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPSADL
DAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALRVGDPTDPDTDVGP
LATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRPGWFYPPTVITDISKDMALYTEEVFGP
VASVFRAANIDEAVEIANATTFGLGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPEL
PFGGVKRSGYGRELSAHGIREFCNIKTVWIA