Protein Info for Rv0158 in Mycobacterium tuberculosis H37Rv

Annotation: Probable transcriptional regulatory protein (possibly TetR-family)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 214 PF00440: TetR_N" amino acids 16 to 57 (42 residues), 47.8 bits, see alignment 1.5e-16 PF17932: TetR_C_24" amino acids 81 to 196 (116 residues), 75.5 bits, see alignment E=6.2e-25 PF08360: TetR_C_5" amino acids 81 to 195 (115 residues), 21.2 bits, see alignment E=4.3e-08

Best Hits

KEGG orthology group: None (inferred from 100% identity to mtf:TBFG_10159)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (214 amino acids)

>Rv0158 Probable transcriptional regulatory protein (possibly TetR-family) (Mycobacterium tuberculosis H37Rv)
MPSDTSPNGLSRREELLAVATKLFAARGYHGTRMDDVADVIGLNKATVYHYYASKSLILF
DIYRQAAEGTLAAVHDDPSWTAREALYQYTVRLLTAIASNPERAAVYFQEQPYITEWFTS
EQVAEVREKEQQVYEHVHGLIDRGIASGEFYECDSHVVALGYIGMTLGSYRWLRPSGRRT
AKEIAAEFSTALLRGLIRDESIRNQSPLGTRKET