Protein Info for Rv0135c in Mycobacterium tuberculosis H37Rv

Annotation: Possible transcriptional regulatory protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 201 PF00440: TetR_N" amino acids 20 to 66 (47 residues), 54.2 bits, see alignment 4.8e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to mtu:Rv0135c)

Predicted SEED Role

"Transcriptional regulator, TetR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (201 amino acids)

>Rv0135c Possible transcriptional regulatory protein (Mycobacterium tuberculosis H37Rv)
VTAVAAGALVVETDSFRLRLLDGLVASIGERGYRATTVSDIVRHARTSKRTFYDRFTSKE
QCFLELLLADNETLGNSIRAAVDPNADWHDQIRQAVEAYVTHIESRPAVTLSWIREFPSL
GAAAYPVQRRGMEQLTSLLIELSASPGFRRANLPPLNVPLAVILLGGLRELTALTVEDGQ
PIRNIVEPAVDASIALLGPRS