Protein Info for Rv0125 in Mycobacterium tuberculosis H37Rv

Annotation: Probable serine protease PepA (serine proteinase) (MTB32A)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 355 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details PF00089: Trypsin" amino acids 79 to 243 (165 residues), 43.3 bits, see alignment E=8.1e-15 PF13365: Trypsin_2" amino acids 79 to 222 (144 residues), 91.4 bits, see alignment E=2e-29 PF00595: PDZ" amino acids 267 to 319 (53 residues), 28.2 bits, see alignment 4e-10 PF13180: PDZ_2" amino acids 269 to 335 (67 residues), 44.8 bits, see alignment E=2.6e-15

Best Hits

KEGG orthology group: K01362, [EC: 3.4.21.-] (inferred from 100% identity to mbo:Mb0130)

Predicted SEED Role

"PepA"

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (355 amino acids)

>Rv0125 Probable serine protease PepA (serine proteinase) (MTB32A) (Mycobacterium tuberculosis H37Rv)
MSNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFADFPALPLDPSAMVAQVG
PQVVNINTKLGYNNAVGAGTGIVIDPNGVVLTNNHVIAGATDINAFSVGSGQTYGVDVVG
YDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSGGQGGTPRAVPGRVVALGQTV
QASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQVVGMNTAASDNFQLSQGGQGFA
IPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVDNNGNGARVQRVVGSAPAASLGIST
GDVITAVDGAPINSATAMADALNGHHPGDVISVTWQTKSGGTRTGNVTLAEGPPA