Protein Info for Rv0118c in Mycobacterium tuberculosis H37Rv

Annotation: Probable oxalyl-CoA decarboxylase OxcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 582 TIGR03254: oxalyl-CoA decarboxylase" amino acids 12 to 570 (559 residues), 923.8 bits, see alignment E=1.9e-282 PF02776: TPP_enzyme_N" amino acids 15 to 129 (115 residues), 109.9 bits, see alignment E=1.1e-35 PF00205: TPP_enzyme_M" amino acids 206 to 335 (130 residues), 112.2 bits, see alignment E=2.5e-36 PF02775: TPP_enzyme_C" amino acids 408 to 552 (145 residues), 95.8 bits, see alignment E=3.5e-31

Best Hits

Swiss-Prot: 60% identical to OXC_ECO57: Oxalyl-CoA decarboxylase (oxc) from Escherichia coli O157:H7

KEGG orthology group: K01577, oxalyl-CoA decarboxylase [EC: 4.1.1.8] (inferred from 100% identity to mra:MRA_0125)

MetaCyc: 60% identical to oxalyl-CoA decarboxylase (Escherichia coli K-12 substr. MG1655)
Oxalyl-CoA decarboxylase. [EC: 4.1.1.8]

Predicted SEED Role

"Oxalyl-CoA decarboxylase (EC 4.1.1.8)" in subsystem Alkaloid biosynthesis from L-lysine (EC 4.1.1.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (582 amino acids)

>Rv0118c Probable oxalyl-CoA decarboxylase OxcA (Mycobacterium tuberculosis H37Rv)
MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARAAQASGIRYIGFRHEA
SAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCFPMIQISGSSSRPMVDLQR
GDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTATSGRPGGVYLDIPGDVLGQAV
EASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLVLSKGAAYAQADNVIREFV
EHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLLVGARLNWLLGNGESPQWSA
DAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSALLEAAADRSSVASAAWTGELADRKAR
NSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVNEGANALDLARNIIDMHLPRHR
LDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGFSGMEFETICRYRLPVTVVILNN
GGVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELIAEAFGGKGYHVSTPTELESALTD
ALASNGPSLIDCELDPADGVESGHLAKLNTTSAATPAISGDG