Protein Info for Rv0107c in Mycobacterium tuberculosis H37Rv

Annotation: Probable cation-transporter ATPase I CtpI

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1632 transmembrane" amino acids 972 to 989 (18 residues), see Phobius details amino acids 1001 to 1019 (19 residues), see Phobius details amino acids 1399 to 1419 (21 residues), see Phobius details amino acids 1432 to 1452 (21 residues), see Phobius details amino acids 1493 to 1510 (18 residues), see Phobius details amino acids 1522 to 1539 (18 residues), see Phobius details amino acids 1546 to 1568 (23 residues), see Phobius details PF00122: E1-E2_ATPase" amino acids 852 to 1029 (178 residues), 122.7 bits, see alignment E=2.5e-39 TIGR01494: HAD ATPase, P-type, family IC" amino acids 854 to 1080 (227 residues), 105.5 bits, see alignment E=1.2e-34 amino acids 1304 to 1419 (116 residues), 95.2 bits, see alignment 1.6e-31 PF00702: Hydrolase" amino acids 1047 to 1352 (306 residues), 69.8 bits, see alignment E=8.7e-23 PF13246: Cation_ATPase" amino acids 1108 to 1178 (71 residues), 28.9 bits, see alignment (E = 2e-10) PF00689: Cation_ATPase_C" amino acids 1427 to 1570 (144 residues), 38.8 bits, see alignment E=1.7e-13

Best Hits

Swiss-Prot: 100% identical to CTPI_MYCTU: Probable cation-transporting ATPase I (ctpI) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K12955, cation-transporting ATPase I [EC: 3.6.3.-] (inferred from 100% identity to mra:MRA_0112)

Predicted SEED Role

"Probable cation-transporting ATPase I (EC 3.6.3.-)" (EC 3.6.3.-)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-

Use Curated BLAST to search for 3.6.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1632 amino acids)

>Rv0107c Probable cation-transporter ATPase I CtpI (Mycobacterium tuberculosis H37Rv)
VKIPGVATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLELTGPVVQSVVQTTGRA
IGVRGSHNESPDGMTPPVRWRSGRRVHFDLDPLLPFPRWHEHAAMVEEPVRRIPGVAEAH
VEGSLGRLVVELEPDADSDIAVDEVRDVVSAVAADIFLAGSVSSPNSAPFADPGNPLAIL
VPLTAAAMDLVAMGATVTGWVARLPAAPQTTRALAALINHQPRMVSLMESRLGRVGTDIA
LAATTAAANGLTQSLGTPLLDLVQRSLQISEAAAHRRVWRDREPALASPRRPQAPVVPII
SSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAAIDTAKGSRAGPVEQYVNQAANGSLIA
AASALVAGGGTEDAAGAILAGVPRAAHMGRQAFAAVLGRGLANTGQLVLDPGALRRLDRV
RVVVIDGAALRGDNRAVLHAQGDEPGWDDDRVYEVADALLHGEQAPEPDPDELPATGARL
RWAPAQGPSATPAQGLEHADLVVDGQCVGSVDVGWEVDPYAIPLLQTAHRTGARVVLRHV
AGTEDLSASVGSTHPPGTPLLKLVRELRADRGPVLLITAVHRDFASTDTLAALAIADVGV
ALDDPRGATPWTADLITGTDLAAAVRILSALPVARAASESAVHLAQGGTTLAGLLLVTGE
QDKTTNPASFRRWLNPVNAAAATALVSGMWSAAKVLRMPDPTPQPLTAWHALDPEIVYSR
LAGGSRPLAVEPGIPAWRRILDDLSYEPVMAPLRGPARTLAQLAVATRHELADPLTPILA
VGAAASAIVGSNIDALLVAGVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVA
TTRRRLEAARHATRTATVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLEVDESFLTGES
LPVDKQVDPVAVNDPDRASMLFEGSTIVAGHARAIVVATGVGTAAHRAISAVADVETAAG
VQARLRELTSKVLPMTLAGGAAVTALALLRRASLRQAVADGVAIAVAAVPEGLPLVATLS
QLAAAQRLTARGALVRSPRTIEALGRVDTICFDKTGTLTENRLRVVCALPSSTAAERDPL
PQTTDAPSAEVLRAAARASTQPHNGEGHAHATDEAILAAASALAGSLSSQGDSEWVVLAE
VPFESSRGYAAAIGRVGTDGIPMLMLKGAPETILPRCRLADPGVDHEHAESVVRHLAEQG
LRVLAVAQRTWDNGTTHDDETDADAVDAVAHDLELIGYVGLADTARSSSRPLIEALLDAE
RNVVLITGDHPITARAIARQLGLPADARVVTGAELAVLDEEAHAKLAADMQVFARVSPEQ
KVQIVAALQRCGRVTAMVGDGANDAAAIRMADVGIGVSGRGSSAARGAADIVLTDDDLGV
LLDALVEGRSMWAGVRDAVTILVGGNVGEVLFTVIGTAFGAGRAPVGTRQLLLVNLLTDM
FPALAVAVTSQFAEPDDAEYPTDDAAERAQREHRRAVLIGPTPSLDAPLLRQIVNRGVVT
AAGATAAWAIGRWTPGTERRTATMGLTALVMTQLAQTLLTRRHSPLVIATALGSAGVLVG
IIQTPVISHFSGVPRWDRSPGRASSAPRQEPPQSQRWHRSGWQAQSVSCNLMNALTTRKT
LTRVDRTYRRPR