Protein Info for Rv0092 in Mycobacterium tuberculosis H37Rv

Annotation: Cation transporter P-type ATPase a CtpA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 761 transmembrane" amino acids 99 to 123 (25 residues), see Phobius details amino acids 129 to 149 (21 residues), see Phobius details amino acids 162 to 184 (23 residues), see Phobius details amino acids 204 to 223 (20 residues), see Phobius details amino acids 361 to 380 (20 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 693 to 711 (19 residues), see Phobius details amino acids 717 to 735 (19 residues), see Phobius details PF00403: HMA" amino acids 18 to 76 (59 residues), 45.6 bits, see alignment 1.5e-15 TIGR01525: heavy metal translocating P-type ATPase" amino acids 164 to 737 (574 residues), 557.7 bits, see alignment E=7e-171 TIGR01511: copper-translocating P-type ATPase" amino acids 204 to 738 (535 residues), 495.7 bits, see alignment E=3.9e-152 TIGR01494: HAD ATPase, P-type, family IC" amino acids 214 to 715 (502 residues), 267.7 bits, see alignment E=3.2e-83 PF00122: E1-E2_ATPase" amino acids 243 to 420 (178 residues), 163.1 bits, see alignment E=1e-51 PF00702: Hydrolase" amino acids 437 to 649 (213 residues), 125.1 bits, see alignment E=9.4e-40

Best Hits

Swiss-Prot: 100% identical to CTPA_MYCTO: Copper-exporting P-type ATPase (ctpA) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K12949, cation-transporting P-type ATPase A/B [EC: 3.6.3.-] (inferred from 100% identity to mbt:JTY_0096)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-, 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.- or 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (761 amino acids)

>Rv0092 Cation transporter P-type ATPase a CtpA (Mycobacterium tuberculosis H37Rv)
MTTAVTGEHHASVQRIQLRISGMSCSACAHRVESTLNKLPGVRAAVNFGTRVATIDTSEA
VDAAALCQAVRRAGYQADLCTDDGRSASDPDADHARQLLIRLAIAAVLFVPVADLSVMFG
VVPATRFTGWQWVLSALALPVVTWAAWPFHRVAMRNARHHAASMETLISVGITAATIWSL
YTVFGNHSPIERSGIWQALLGSDAIYFEVAAGVTVFVLVGRYFEARAKSQAGSALRALAA
LSAKEVAVLLPDGSEMVIPADELKEQQRFVVRPGQIVAADGLAVDGSAAVDMSAMTGEAK
PTRVRPGGQVIGGTTVLDGRLIVEAAAVGADTQFAGMVRLVEQAQAQKADAQRLADRISS
VFVPAVLVIAALTAAGWLIAGGQPDRAVSAALAVLVIACPCALGLATPTAMMVASGRGAQ
LGIFLKGYKSLEATRAVDTVVFDKTGTLTTGRLQVSAVTAAPGWEADQVLALAATVEAAS
EHSVALAIAAATTRRDAVTDFRAIPGRGVSGTVSGRAVRVGKPSWIGSSSCHPNMRAARR
HAESLGETAVFVEVDGEPCGVIAVADAVKDSARDAVAALADRGLRTMLLTGDNPESAAAV
ATRVGIDEVIADILPEGKVDVIEQLRDRGHVVAMVGDGINDGPALARADLGMAIGRGTDV
AIGAADIILVRDHLDVVPLALDLARATMRTVKLNMVWAFGYNIAAIPVAAAGLLNPLVAG
AAMAFSSFFVVSNSLRLRKFGRYPLGCGTVGGPQMTAPSSA