Protein Info for Rv0019c in Mycobacterium tuberculosis H37Rv

Annotation: Conserved protein with FHA domain, FhaB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 155 transmembrane" amino acids 7 to 28 (22 residues), see Phobius details PF16697: Yop-YscD_cpl" amino acids 66 to 154 (89 residues), 58.2 bits, see alignment E=8e-20 PF00498: FHA" amino acids 83 to 147 (65 residues), 61.2 bits, see alignment E=1e-20

Best Hits

Swiss-Prot: 100% identical to FHAB_MYCTU: FHA domain-containing protein FhaB (fhaB) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mtb:TBMG_00019)

Predicted SEED Role

"FIG00818182: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (155 amino acids)

>Rv0019c Conserved protein with FHA domain, FhaB (Mycobacterium tuberculosis H37Rv)
MQGLVLQLTRAGFLMLLWVFIWSVLRILKTDIYAPTGAVMMRRGLALRGTLLGARQRRHA
ARYLVVTEGALTGARITLSEQPVLIGRADDSTLVLTDDYASTRHARLSMRGSEWYVEDLG
STNGTYLDRAKVTTAVRVPIGTPVRIGKTAIELRP