Protein Info for RS_RS24645 in Ralstonia solanacearum GMI1000

Annotation: cytochrome c oxidase subunit I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 586 transmembrane" amino acids 28 to 49 (22 residues), see Phobius details amino acids 74 to 97 (24 residues), see Phobius details amino acids 113 to 133 (21 residues), see Phobius details amino acids 159 to 182 (24 residues), see Phobius details amino acids 202 to 227 (26 residues), see Phobius details amino acids 262 to 286 (25 residues), see Phobius details amino acids 298 to 319 (22 residues), see Phobius details amino acids 326 to 348 (23 residues), see Phobius details amino acids 362 to 384 (23 residues), see Phobius details amino acids 397 to 422 (26 residues), see Phobius details amino acids 438 to 458 (21 residues), see Phobius details amino acids 483 to 506 (24 residues), see Phobius details TIGR02891: cytochrome c oxidase, subunit I" amino acids 19 to 539 (521 residues), 689.3 bits, see alignment E=1.5e-211 PF00115: COX1" amino acids 28 to 490 (463 residues), 473 bits, see alignment E=4.8e-146

Best Hits

Swiss-Prot: 78% identical to COXN_BRADU: Alternative cytochrome c oxidase subunit 1 (coxN) from Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)

KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 100% identity to rso:RSp1565)

Predicted SEED Role

"Alternative cytochrome c oxidase polypeptide CoxN (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8XPS3 at UniProt or InterPro

Protein Sequence (586 amino acids)

>RS_RS24645 cytochrome c oxidase subunit I (Ralstonia solanacearum GMI1000)
MSYAHPDHEHGPQSFWTRYVWSQDHKVIAVQYSLTAIAIGLVGLVLSNLMRLQLGFPGRF
AFIDANHYYQFVTMHGMIMVIYLLTALFLGGFGNYLIPLMLGARDMVFPFLNMLSYWVYL
LAVLVLVASFFVPGGPTGAGWTLYPPQAILPGTPGTELGIVLMLVSLAIFIVAATMGGLN
YVTTTLQARTRGMTLLRMPLTVWGIFMATILALLAFPALFVSAIMMLLDKTLGTSFFVPA
VVSMGQHLKHAGGSPLLFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYKMMV
WAIIIIGVLSFVVWAHHMFVAGMNPYFGFFFATTTLIIAIPTALKVYNWVLTLWRGDIHL
TVPMLFAIGFISTFVIGGLTGLFLGNVSVDIPLSNTYFVVAHFHMVMGVSPILVVFGGLY
HWYPKVTGRMLNDTLGRVHFWITFIGTYLIYFPMHYLGVLGMPRRYYAYEGYSFIPPSAQ
TLNTVITVIALAVGAAQLLFLVNLAWSLVRGRKADSNPWRATTLEWQTPQTPPVHGNWGP
ALPVVYRWAYEYSPPDRTEDFVPQNEPPPGTPGAQADILRAGGVRA