Protein Info for RS_RS22915 in Ralstonia solanacearum GMI1000

Annotation: multidrug transporter subunit MdtB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1041 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 334 to 353 (20 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 463 to 483 (21 residues), see Phobius details amino acids 529 to 548 (20 residues), see Phobius details amino acids 858 to 876 (19 residues), see Phobius details amino acids 883 to 902 (20 residues), see Phobius details amino acids 908 to 932 (25 residues), see Phobius details amino acids 955 to 975 (21 residues), see Phobius details amino acids 988 to 1013 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1013 (1010 residues), 1118.5 bits, see alignment E=0 PF03176: MMPL" amino acids 328 to 496 (169 residues), 31.5 bits, see alignment E=9.4e-12

Best Hits

Swiss-Prot: 69% identical to MDTB_CROS8: Multidrug resistance protein MdtB (mdtB) from Cronobacter sakazakii (strain ATCC BAA-894)

KEGG orthology group: K07788, RND superfamily, multidrug transport protein MdtB (inferred from 70% identity to axy:AXYL_00555)

MetaCyc: 67% identical to multidrug efflux pump RND permease subunit MdtB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8XQM4 at UniProt or InterPro

Protein Sequence (1041 amino acids)

>RS_RS22915 multidrug transporter subunit MdtB (Ralstonia solanacearum GMI1000)
MNPSRIFILRPVATTLLMVAILLSGLVAYRMLPLSALPEVDYPTIQVTTLYPGASPDVMT
SSITAPLERQFGQMPGLKQMTSASSGGASVITLQFDLSLSLDIAEQEVQAAINAAGNLLP
TDLPMPPIYSKVNPADAPILTLAITSRTLPLPKLEDIVDTRVAQKLSQLPGIGLVSISGG
QRPAVRIQANTQALAALGLSIDDIRTAIGNANVNGAKGSFDGPMRASTIDANDQLRSAAE
YGTMIVAYKNGAPIRLTDVAQIIDGAENSKLAAWANTTPAIILNVQRQPGANVIDVVNRA
KALLPQLKDTLPANIDVAVLTDRTTTIRASVADVQFELLLAVALVVMVIFLFLRNIPATI
IPAVAVPLSLVGTFGVMYLAGFSVNNLTLMALTIATGFVVDDAIVMIENIARYIEDGDPP
MEAALKGARQIGFTIISLTFSLIAVLIPLLFMSDVVGRLFREFAITLAVSILISAVVSLT
LTPMMCARLLRHIPEPEQTRFYHAAGQFFDNVIAQYGRMLQWVLDRQRTTLLVAIGTLAL
TGLLYVYVPKGFFPVQDTGVIQGISDATQSISFPAMAERQQKLAEVILKDPAVESLSSFI
GVDGTNTTLNSGRMLINLKPKDARDADATEIIQRLQPELAKVGGISLFMQPVQDLTIEDR
VSRTQYQFTVEDPDPNNLSKWVPRLVERLQQTGELRDVASDLQDNGLRAYVQIDRDKAAV
YGVTTAAVDSALYSAYGQRLISTIFTQSNQYRVVLEAAPQLQKGPQSLYDLRVASTGGQQ
VPLGAFATVVEQPGSLVVNHQGQFPSATISFNLARGASLGAAVDAINAAEQAIGLPASMQ
TSFQGAALAFQSSLSNELWLILAAIITMYIVLGVLYESTIHPVTILSTLPSAGVGALLSL
LVSGKDMGIIAIIGIILLIGIVKKNAIMMIDFALEAEREQGMAPRDAIYQACLLRFRPIL
MTTMAALLGALPLMLGTGVGSELRQPLGITMVGGLLVSQVLTLFTTPVIYLAFDSLGHRL
RDWRERRAARRTGADQSGSQP