Protein Info for RS_RS16300 in Ralstonia solanacearum GMI1000

Annotation: TlpA family protein disulfide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 172 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF08534: Redoxin" amino acids 30 to 159 (130 residues), 55.9 bits, see alignment E=8.8e-19 PF00578: AhpC-TSA" amino acids 36 to 146 (111 residues), 48.2 bits, see alignment E=2.1e-16 PF00085: Thioredoxin" amino acids 56 to 125 (70 residues), 24.1 bits, see alignment E=6e-09 PF13905: Thioredoxin_8" amino acids 58 to 144 (87 residues), 30.5 bits, see alignment E=7.6e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to rso:RSc3254)

Predicted SEED Role

"Thiol:disulfide interchange protein, thioredoxin family" in subsystem Sulfur oxidation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8XUD7 at UniProt or InterPro

Protein Sequence (172 amino acids)

>RS_RS16300 TlpA family protein disulfide reductase (Ralstonia solanacearum GMI1000)
MRTMRRIRGWLAAALVPMALAAGAAHAVEVGDTVTLPDLQLLDGTRVPSESWRGHPAVIA
TWASWCPYCALQNPRLQKLYDATRGTGLRVLTISIDANPRLAGDYIAKRGFTFPVTMESD
ALCAATGPRKGLPELLVLDADGRVVQKATGEMLEDDIADLARYAHGTQAPAR