Protein Info for RS_RS15390 in Ralstonia solanacearum GMI1000

Annotation: two-component sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 130 to 155 (26 residues), see Phobius details PF00512: HisKA" amino acids 208 to 272 (65 residues), 42.2 bits, see alignment E=6.6e-15 PF02518: HATPase_c" amino acids 319 to 427 (109 residues), 90.3 bits, see alignment E=1.2e-29

Best Hits

KEGG orthology group: K02484, two-component system, OmpR family, sensor kinase [EC: 2.7.13.3] (inferred from 100% identity to rso:RSc3063)

Predicted SEED Role

"Sensory histidine kinase in two-component regulatory system with RstA" in subsystem Orphan regulatory proteins

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8XUX0 at UniProt or InterPro

Protein Sequence (433 amino acids)

>RS_RS15390 two-component sensor histidine kinase (Ralstonia solanacearum GMI1000)
MFRSTLKLSLMMLVAGAIAVQALSWSAGRLFHDTLTQGQREGRKGYVFLLREYLDRFPGE
ARATAIQRLNNNATELFDMVEPDTVADLSTEQRRDLADGKLVVMTNRMDYYLPLRDGTVL
HARFEDIGYYTAIKIIAFCLIAIATLLPILFWSWLLWRDLRALEEAARGFGGGMLSTRAH
LRRGSNVHALARQFNDMAERIQGSIQHQREMMNGISHELKTPIARLEFGIALLQSPVPED
QRKARFDALRSDVRELDELVTELLALSRLEQGATHLVLMRVTVGEWLDSVVANIADDVAD
RQLTLAVHADFAPAHHVCDPRLVARALLNLIRNAMRYARQAITVRAEAGTYGSLCLTVED
DGPGIPAAERARVFEPFYRLDASRDRHTGGFGLGLAIVRRIALVHGGEVRLDTGGSGGAR
FVLLLPAMPLPMQ