Protein Info for RS_RS13695 in Ralstonia solanacearum GMI1000

Annotation: hybrid sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 374 PF00072: Response_reg" amino acids 11 to 121 (111 residues), 58.2 bits, see alignment E=1.3e-19 PF00512: HisKA" amino acids 143 to 210 (68 residues), 29.6 bits, see alignment E=8.7e-11 PF02518: HATPase_c" amino acids 266 to 374 (109 residues), 55.5 bits, see alignment E=1.1e-18

Best Hits

KEGG orthology group: K00936, [EC: 2.7.3.-] (inferred from 100% identity to rso:RSc2737)

Predicted SEED Role

"TWO COMPONENT RESPONSE REGULATOR TRANSCRIPTION REGULATOR PROTEIN"

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8XVU0 at UniProt or InterPro

Protein Sequence (374 amino acids)

>RS_RS13695 hybrid sensor histidine kinase/response regulator (Ralstonia solanacearum GMI1000)
MDATPDTGPTILYVDDEQQACKWFTRMVSASYNVLTANSVEEAKAVLRDAHDRIGVVLTD
FRMPGGDGTELLRFIDAEYSDIAAILVTAYADKDLLIQAVNTGRVFKILEKPYQPEDVRR
SLQEALALRQDRLLRTQRLMAIDETLAFLAHELNTPLAAIANFARGIRMRVDQTEPAPDT
LPGIGRAADRVQDNARYCLSVLSTFLNSVRHAHGKSEAASASAPSSAAGLIRSLLDTYPF
TAVQRDWVSYRIERDFPILTLPNCVMLVLSSLTSNALHALRHTEAPRLEIVAAGAAALNG
TPGAGHTIRIEDNGPGIAPDILARLTIDPVTTRAEEGGNGMGMIFCTRIMQSFGGGIAID
SAPSAGTRVTLTFP