Protein Info for RS_RS11875 in Ralstonia solanacearum GMI1000

Annotation: lysine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03709: OKR_DC_1_N
  • amino acids 20 to 146 (127 residues), 116.2 bits, E=1.4e-37
• PF01276: OKR_DC_1
  • amino acids 152 to 593 (442 residues), 511.5 bits, E=2.5e-157
• PF03711: OKR_DC_1_C
  • amino acids 620 to 745 (126 residues), 164.8 bits, E=1.9e-52

Best Hits

KEGG orthology group: K01582, lysine decarboxylase [EC: 4.1.1.18] (inferred from 80% identity to bcn:Bcen_1821)

Predicted SEED Role

"Arginine decarboxylase (EC 4.1.1.19); Ornithine decarboxylase (EC 4.1.1.17); Lysine decarboxylase (EC 4.1.1.18)" (EC 4.1.1.17, EC 4.1.1.18, EC 4.1.1.19)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (16/17 steps found)
• superpathway of polyamine biosynthesis I (7/8 steps found)
• superpathway of putrescine biosynthesis (4/4 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (2/2 steps found)
• putrescine biosynthesis I (2/2 steps found)
• putrescine biosynthesis III (2/2 steps found)
• arginine dependent acid resistance (1/1 steps found)
• cadaverine biosynthesis (1/1 steps found)
• aminopropylcadaverine biosynthesis (2/3 steps found)
• L-lysine degradation X (4/6 steps found)
• superpathway of polyamine biosynthesis II (5/8 steps found)
• spermidine biosynthesis III (2/4 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (1/3 steps found)
• putrescine biosynthesis II (1/3 steps found)
• superpathway of ornithine degradation (4/8 steps found)
• L-lysine degradation I (3/7 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• bisucaberin biosynthesis (1/5 steps found)
• desferrioxamine B biosynthesis (1/5 steps found)
• desferrioxamine E biosynthesis (1/5 steps found)
• lupanine biosynthesis (1/5 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• superpathway of hyoscyamine (atropine) and scopolamine biosynthesis (4/16 steps found)
• superpathway of L-lysine degradation (9/43 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Glutathione metabolism
• Lysine degradation
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.17 or 4.1.1.18 or 4.1.1.19

Sequence Analysis Tools

See Q8XWV5 at UniProt or InterPro

Protein Sequence (759 amino acids)

>RS_RS11875 lysine decarboxylase (Ralstonia solanacearum GMI1000)
MKFRFPVIIIDEDFRSENISGSGIRALAQAIEEEGMEVTGLTSYGDLTSFAQQSSRASTF
IVSIDDDEFINPDNDKPEPEAVENLRSFVAEVRRRNANIPIFLYGETRTSRHLPNDILRE
LHGFIHMFEDTPEFVARHIIREARNYLDSLPPPFFKALIDYAQDSSYSWHCPGHSGGVAF
LKSPVGQVFHQFFGENMLRADVCNAVDELGQLLDHTGPVAASERNAARIFGSDHMFFVTN
GTSTSNKMVWHANVAPGDIVVVDRNCHKSILHAIMMTGAIPVFLMPTRNHYGIIGPIPQS
EFEPETIARKIAEHPFASQAANKKPRILTLTQGTYDGVLYNAERIKHMLSTEIDTLHFDE
AWLPHASFHPFYRDMHAIGQGRARSKDALVFATQSTHKLLAGLSQASQILVQDSETRKLD
TYRFNEAYLMHTSTSPQYSIIASCDVAAAMMEAPGGTALVEESIAEALDFRRAMRKVEQE
YVGTNGGNGRGDDWWFKVWGPNDLSDEGIEEREAWMLKANERWHGFGDLAEDFNLLDPIK
ATIITPGLDVDGKFSESGIPAAIVTKYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSMV
TELQQFKDDYDNNQPLWRVLPEFVRQYPQYERIGLRELCDAIHSVYKANDVARVTTEMYL
SNMEPAMKPSDAWAKMAHRETERVAIDDLEGRITAILLTPYPPGIPLLIPGERFNRTIVQ
YLQFAREFNKLFPGFETDIHGLVEEEIEGRVGYFVDCVR