Protein Info for RS_RS07765 in Ralstonia solanacearum GMI1000

Annotation: glutamate-1-semialdehyde aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00202: Aminotran_3
  • amino acids 35 to 208 (174 residues), 64.7 bits, E=3.2e-22

Predicted SEED Role

"Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 5.4.3.8)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (29/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (29/36 steps found)
• superpathway of heme b biosynthesis from glutamate (9/10 steps found)
• tetrapyrrole biosynthesis I (from glutamate) (6/6 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.4.3.8

Use Curated BLAST to search for 5.4.3.8

Protein Sequence (249 amino acids)

>RS_RS07765 glutamate-1-semialdehyde aminotransferase (Ralstonia solanacearum GMI1000)
MFELRYNDPNHAAHLVSKHGRDLAAIVMMPYEIDPPVAGHLHCMQALARKAGALFVLDEV
RSGFRIALGGAQSYFGFEPDLSAFGKALGNGYCISALAGRACHMRHILKLGLTVTHYRSP
DVMAAAVATLEALDRSDVPARLTALGERLMSGLDRTFATSGVPGRAVGFPATPFVRFDDP
RPNVRDSMVRHFINGMLAEGVLMCPAHHWFLCAAMTDADVDAIVTAAERVLAGPRGTIDP
HAPSPPGAA