Protein Info for RS_RS06385 in Ralstonia solanacearum GMI1000

Annotation: copper-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 847 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 205 to 226 (22 residues), see Phobius details amino acids 240 to 261 (22 residues), see Phobius details amino acids 273 to 295 (23 residues), see Phobius details amino acids 301 to 319 (19 residues), see Phobius details amino acids 455 to 477 (23 residues), see Phobius details amino acids 483 to 509 (27 residues), see Phobius details amino acids 801 to 820 (20 residues), see Phobius details amino acids 826 to 843 (18 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 32 to 116 (85 residues), 69.4 bits, see alignment E=1.1e-22 PF00403: HMA" amino acids 126 to 185 (60 residues), 44.1 bits, see alignment 6.7e-15 TIGR01511: copper-translocating P-type ATPase" amino acids 257 to 843 (587 residues), 445.7 bits, see alignment E=5.8e-137 TIGR01525: heavy metal translocating P-type ATPase" amino acids 275 to 843 (569 residues), 489.9 bits, see alignment E=2.4e-150 TIGR01494: HAD ATPase, P-type, family IC" amino acids 311 to 568 (258 residues), 108.3 bits, see alignment E=6.8e-35 amino acids 643 to 818 (176 residues), 108.3 bits, see alignment E=6.9e-35 PF00122: E1-E2_ATPase" amino acids 338 to 516 (179 residues), 150.2 bits, see alignment E=1.4e-47 PF00702: Hydrolase" amino acids 535 to 754 (220 residues), 82.4 bits, see alignment E=1.8e-26 PF08282: Hydrolase_3" amino acids 729 to 776 (48 residues), 22 bits, see alignment 3.7e-08

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to rso:RSc1274)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8XZX1 at UniProt or InterPro

Protein Sequence (847 amino acids)

>RS_RS06385 copper-translocating P-type ATPase (Ralstonia solanacearum GMI1000)
MTTTLAPILAAAPGVGSVSSGRPDDAQASHVTCYHCGASLDGDAALHAEMAGQSRDFCCA
GCQTIAMTLHASGMGHVYDGPIAFARPIDGEVRTEAEAAWATYDLPVMRERFVRTRKDGA
EEVSLTLAGMRCAACVWLIERALARVPGVREAIVNYATERVRIVSDAGAVRLADLFAAIA
DVGYEAWPDQPSTRRAAEARERRQLLIRLGIAMLGMMQVMMYAWPVYLHGGSIPADQVML
MQWASLALTTPVVLFSAGPIFRNAWRQVRHAHVGMDVPVALGVGAAFAASVAAMVRGHGE
TYFDSVTMFVAFLLAARYLELRARQSATSGTEALVRQLPATCRRIADGAEAMQTVPVAAL
QVGDCVEVRAGEILPADGVIERGTTEIDESLLSGESVPQPRGIGAMVLAGSYNAASAIWL
RVHRVGAQTRLAAIVELLERALTDKPRMAELADRVAGRFVMVLLGWAVLTALAWWWIDPD
RMFAVTVAVLVVSCPCALSLATPSALAAASGALARRGVLITRGHAIESLAAVTDVLLDKT
GTLTQGHLRLLSIETFDDPDAQQCLALACALEQAENHPIAQSLRAAAAQGRVPAVAVSDV
LNVPGQGVRARLQMQDIRLGTQAFAAQAFDGQPPHATAHVSGEPAEDVPSAACTAIWLGC
DGHPLARFVLADTPRADAAACLDALRAQDLRLHLVSGDAPQTVRWWAARLGIAHAVGGAS
PEDKRAYVRALQAGGARVLAVGDGINDAPLLAQAQVSIAIGTGAPLAQAGADAILTEPRL
PAIGEAVSIGRRTLRVVRQNLGWAFAYNAVSIPLATLGWLSPLEAGIGMSVSSLLVALNA
WRLSRVA