Protein Info for RS_RS06135 in Ralstonia solanacearum GMI1000

Annotation: ATP phosphoribosyltransferase regulatory subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 386 PF13393: tRNA-synt_His" amino acids 10 to 313 (304 residues), 426 bits, see alignment E=4.4e-132 TIGR00443: ATP phosphoribosyltransferase, regulatory subunit" amino acids 12 to 314 (303 residues), 288.3 bits, see alignment E=3.4e-90

Best Hits

Swiss-Prot: 100% identical to HISZ_RALSO: ATP phosphoribosyltransferase regulatory subunit (hisZ) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K02502, ATP phosphoribosyltransferase regulatory subunit (inferred from 100% identity to rso:RSc1225)

Predicted SEED Role

"ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)" in subsystem Histidine Biosynthesis (EC 2.4.2.17)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8Y020 at UniProt or InterPro

Protein Sequence (386 amino acids)

>RS_RS06135 ATP phosphoribosyltransferase regulatory subunit (Ralstonia solanacearum GMI1000)
MPNWLLPESIADVLPSEARKIEELRRRMLDLFRTYGYELVMPPMLEYIESLLSGTGHDLD
LKTFKLVDQLSGRTIGLRADITPQVARIDAHLLNRAGVTRLCYAGSVLHTRPSGFHVTRE
PLQIGAEIYGHAGLEADLEIQDLMLAALSAAGLADVRLDLCHVGVLAALLAQAPVAPDVQ
DELFAALASKDAPALHALTAGLPAAQRDAINLLPSLYGGVDVLARARAQLPQLPAIGRAL
DDLATLAAHAGGAAVNIDLADLRGYHYHSGVMFAAYVAGVPNAVARGGRYDKVGEAFGRA
RPATGFSLDLREVAGISPVQARAAAIHAPWSGDAKLREAIAGLRATGEIVIQSLPGHPED
LEEFAYDRQLAEEGGRWVVKPRKASA