Protein Info for RS_RS06125 in Ralstonia solanacearum GMI1000

Annotation: protease modulator HflC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01145: Band_7
  • amino acids 23 to 200 (178 residues), 120.4 bits, E=4.5e-39
• TIGR01932: HflC protein
  • amino acids 144 to 284 (141 residues), 155.5 bits, E=7.7e-50

Best Hits

Swiss-Prot: 44% identical to HFLC_HAEIN: Protein HflC (hflC) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K04087, membrane protease subunit HflC [EC: 3.4.-.-] (inferred from 100% identity to rso:RSc1223)

Predicted SEED Role

"HflC protein" in subsystem Hfl operon

KEGG Metabolic Maps

• Biotin metabolism
• Lysine degradation
• Peptidoglycan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 3.4.-.-

Use Curated BLAST to search for 3.4.-.-

Sequence Analysis Tools

See Q8Y022 at UniProt or InterPro

Protein Sequence (304 amino acids)

>RS_RS06125 protease modulator HflC (Ralstonia solanacearum GMI1000)
MNRLISALVALVIALAVLSSVVFVVDQRQYAVVFAFGEIKQVIKEPGLHFKLPPPLQNVI
FMDKRLMTIDVAGADRFITAEKKNLLVDWFVKWRVSDPRLFYVSFKGDNRLAQDSMTQKI
NSIARDEFARRTVSDVVSTDREAVMQSILKGVQEYGRSVGVDIIDVRLKRVDLLASVTES
VYRRMEAERKRVANELRSTGAAEGEKIRADADRQREVVLADAYREAQKIKGEGDARAADI
YADAFGRDPQFAAFWRSMEAYRASFRDRKDVMVLQPGSDFFKFMRGPNGGGQSVAPAAQA
GRHR