Protein Info for RS_RS05915 in Ralstonia solanacearum GMI1000

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details transmembrane" amino acids 49 to 71 (23 residues), see Phobius details amino acids 89 to 107 (19 residues), see Phobius details amino acids 127 to 146 (20 residues), see Phobius details amino acids 157 to 179 (23 residues), see Phobius details amino acids 191 to 210 (20 residues), see Phobius details amino acids 239 to 261 (23 residues), see Phobius details amino acids 277 to 300 (24 residues), see Phobius details amino acids 313 to 333 (21 residues), see Phobius details amino acids 345 to 368 (24 residues), see Phobius details amino acids 385 to 407 (23 residues), see Phobius details amino acids 419 to 440 (22 residues), see Phobius details PF01554: MatE" amino acids 15 to 173 (159 residues), 89.2 bits, see alignment E=1.2e-29 amino acids 241 to 401 (161 residues), 101 bits, see alignment E=2.9e-33 TIGR00797: MATE efflux family protein" amino acids 15 to 405 (391 residues), 235.6 bits, see alignment E=4.7e-74

Best Hits

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 100% identity to rso:RSc1180)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8Y064 at UniProt or InterPro

Protein Sequence (448 amino acids)

>RS_RS05915 MATE family efflux transporter (Ralstonia solanacearum GMI1000)
MFLADIRSIAALAWPVLVGQLAVIAFGVLDTAMAGRASAADLAAIGLGGSIYVTVYISLM
GVLQALSPIAGQLYGAGRHGEIGEEVRQAAWLGLALSAIGMLLLWFPAPLLRLADASPEL
TSKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVLQLGGLALKFPLNALFLYGGL
GLPAMGGPGCALASMIIGWLWCIAGALILMRNPVYRPFRIFTQFSPPHLGRLWGLVRLGV
PMGLTYLIEITSFTLMAIFIARMGTVVLAGHQIAANVGAVAYMVPLSLSIATSTLVAQMI
GARDRDAARRIAWNGLKLAAACAIAVGGCVLLLRRDLVGLYTRDATVMAIAVPLLPFIAF
YQLFDALQVTAAFILRAYKIALIPTVIYALSLWGVGLGGGYLLGFGLLGESAAALRGAAG
FWAANALSLAVAGTLLVGYFNRISRAAD