Protein Info for RS_RS01630 in Ralstonia solanacearum GMI1000

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 665 transmembrane" amino acids 44 to 68 (25 residues), see Phobius details amino acids 340 to 361 (22 residues), see Phobius details PF00512: HisKA" amino acids 433 to 495 (63 residues), 28.3 bits, see alignment E=2.3e-10 PF02518: HATPase_c" amino acids 543 to 654 (112 residues), 81.7 bits, see alignment E=8.3e-27

Best Hits

KEGG orthology group: K10125, two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC: 2.7.13.3] (inferred from 100% identity to rso:RSc0331)

Predicted SEED Role

"Signal transduction histidine kinase regulating C4-dicarboxylate transport system (EC 2.7.13.3)" (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8Y2K4 at UniProt or InterPro

Protein Sequence (665 amino acids)

>RS_RS01630 sensor histidine kinase (Ralstonia solanacearum GMI1000)
MRHGTERLMAGAAPEGTASPSAVHHPPMSEPDFPFSSASPRRGFGWLVAAALVAVMALVC
ATTFVVTWNRGLSQAQQAAGARVDRYAANLKSTLDRYEYLPALVALHPFIHDLLAHPTPD
NVARANHYLREVNDRARATATYVIAPTGLALAASNYNLPDSFVGAEYLFRPYFQQAAAGH
VGRFYGIGITREEPGYYISQPVMQNGSVIGVTVVKLNLEWFGRASHDASEPVMVADENGV
IFLSSVPAWQYRTVEPLTPELQAQLQATRQYFRKQITPLPLQPEMPAFLKLVGRMPDGAR
LVRVGDRINAPRYLLVSRELVEPDWQLMYLTPIDPVMGAARSATVAAAFAFAFVCLLLFY
WRQRRLRLREMLRGRRLLEAAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAELRAT
QDELVQASKLAALGQMAAGITHELNQPLAALRTFSDNTRILLERGQHGAAADNLRAIADL
TERMGKITAQLKLFAGRSRRRLADVQVRVALDHVLALLRPRLAEVETALHWRLPEAACVV
RADELKLEQVLINLIGNALDAIAANDLPRPGRIDIDIGPADGAPAQLCIVVRDNGPGIAA
DAMPHLFEPFFTTKEIGQGLGLGLAISTSIARDFGGSLSAANVPGGGAQFTLSLVRAEVV
PAATP