Protein Info for RR42_RS37475 in Cupriavidus basilensis FW507-4G11

Annotation: peptide chain release factor 3

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 524 TIGR00503: peptide chain release factor 3" amino acids 1 to 522 (522 residues), 802.3 bits, see alignment E=1.7e-245 PF00009: GTP_EFTU" amino acids 10 to 272 (263 residues), 177.4 bits, see alignment E=6.2e-56 PF01926: MMR_HSR1" amino acids 14 to 141 (128 residues), 24.5 bits, see alignment E=6.2e-09 TIGR00231: small GTP-binding protein domain" amino acids 14 to 150 (137 residues), 68.8 bits, see alignment E=4.8e-23 PF22042: EF-G_D2" amino acids 290 to 376 (87 residues), 90.8 bits, see alignment E=1.2e-29 PF03144: GTP_EFTU_D2" amino acids 309 to 373 (65 residues), 38 bits, see alignment E=4.6e-13 PF16658: RF3_C" amino acids 382 to 508 (127 residues), 149 bits, see alignment E=1.8e-47

Best Hits

Swiss-Prot: 92% identical to RF3_CUPNH: Peptide chain release factor 3 (prfC) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K02837, peptide chain release factor 3 (inferred from 92% identity to cti:RALTA_B2302)

Predicted SEED Role

"Peptide chain release factor 3"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YT15 at UniProt or InterPro

Protein Sequence (524 amino acids)

>RR42_RS37475 peptide chain release factor 3 (Cupriavidus basilensis FW507-4G11)
MSSLVSEIARRRTFAIISHPDAGKTTLTEKLLWFGGAIQVAGEVRARKADRHATSDWMEL
EKQRGISVTSSVMQFPYRENIVNLLDTPGHEDFSEDTYRTLTAVDSAVMVIDSVNGVEAQ
TIKLLNVCRLRDTPIITFINKLDREGRSPIELLDEIEDVLKMQCAPMTWPIGMGKAFRGV
YHLIDDRVQLFDPHGEKGTSAMVQGLDNPELDRVLGTQAEELRIEIELVRGASHAFDKDA
FLSGKQTPVYFGSAVNNFGVQSLLDALCELAPPPQGRNAESRAVEPQEPKFSGFVFKIQA
NMDPRHRDRIAFVRVCSGRFERGMKVLHVSTGKTMAINNAITFMSQDRNTTEEAYAGDII
GVPNHGTIRLGDAFSEGEALKFTGIPSFAPEFFRRARLNNPLKVKQLQKGLQQLAEEGAT
QMFRPIASNDLVLGAVGILQFDVVAHRLEHEYGVDAIFESHDCATARWLKGDPAEIEKLI
EKAGHNVALDGAGDHVYLAPSMVNLRLTQERFPKLQFMETREIV