Protein Info for RR42_RS37040 in Cupriavidus basilensis FW507-4G11

Annotation: sulfite reductase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00258: Flavodoxin_1
  • amino acids 64 to 190 (127 residues), 82.8 bits, E=2.9e-27
• PF00175: NAD_binding_1
  • amino acids 396 to 500 (105 residues), 26.8 bits, E=6.9e-10

Best Hits

KEGG orthology group: K00380, sulfite reductase (NADPH) flavoprotein alpha-component [EC: 1.8.1.2] (inferred from 72% identity to reh:H16_B2500)

Predicted SEED Role

"probable oxidoreductase"

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• assimilatory sulfate reduction I (4/4 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (7/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.2

Use Curated BLAST to search for 1.8.1.2

Sequence Analysis Tools

See A0A0C4YR82 at UniProt or InterPro

Protein Sequence (527 amino acids)

>RR42_RS37040 sulfite reductase subunit alpha (Cupriavidus basilensis FW507-4G11)
MILLGALAGVAGIALGLLAPSRAGMAAGVVIAYAGFCAAVIGRHRQRHARAGQLSEARDG
ATVVAYASQSGFAEQLALQTAQALQDAGVPAQLLSFDQLEAGRLAHCRQALFVVSTTGEG
DAPDSASGFARRLTAAAGAGGLGELRYGILALGDRSYANYCAFGHALSAWMQRQHAQALF
DMVEVDNGDAGALRHWQNHLSALCGGAEIADWEKPRYADWRLHERRLLNPGSPGAPAFHL
ALVPAAVGQGAPSWQAGDIAEIGPRLAPSEVARVLAKLSLDGDTAVRCDGASTTLAQALA
TRIVLPDPHLAALDGVTPQRLVDTLPPLPHREYSIASLPGDGQLDLLVRQTRHDDGRLGL
ASGWLTAHAQPGAGIALRIRTNRGFHPPADDRPLILIGNGTGLAGLRAHLKARAVAGHHR
NWLLFGERTAEHDAFHHVELAAWQANGVLQRLDLVYSRDGGPLRYVQDAVRASAGALREW
IEAGAAIYVCGSLKGMAGGVNAALADVLGEEALLRLGEQGRYRRDVY