Protein Info for RR42_RS35800 in Cupriavidus basilensis FW507-4G11

Annotation: chemotaxis protein CheW

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 164 PF01584: CheW" amino acids 18 to 154 (137 residues), 136.2 bits, see alignment E=3e-44

Best Hits

Swiss-Prot: 69% identical to CHEW_KLEAK: Chemotaxis protein CheW (cheW) from Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006)

KEGG orthology group: K03408, purine-binding chemotaxis protein CheW (inferred from 90% identity to reh:H16_B0240)

Predicted SEED Role

"Positive regulator of CheA protein activity (CheW)" in subsystem Bacterial Chemotaxis or Two-component regulatory systems in Campylobacter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YQI9 at UniProt or InterPro

Protein Sequence (164 amino acids)

>RR42_RS35800 chemotaxis protein CheW (Cupriavidus basilensis FW507-4G11)
MAGIGHIDTPGSEASGQEFLVFTLGSEEYGIDILKVQEIRGYDAVTRLANAPDFIKGVTN
LRGVIVPIVDLRLKFRLGNVRYDHHTVVIILNIAGRVVGIVVDGVSDVLTLTGEAIKPAP
EFGVSVSNDHLTGLGTVDGRMLILIDIEKLMTSAEMELVEAELA